Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis
Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis
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DOI：
10.1038/sj.neo.7900127
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发表时间：
2001-01-01
期刊：
影响因子：
4.8
通讯作者：
Masini, E
中科院分区：
文献类型：
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作者：
Gallo, O;Franchi, A;Masini, E
我们通过分析 COX-2 表达和前列腺素 E-2 (PGE(2)) 产生与肿瘤血管生成和淋巴结转移的关系，评估了 COX-2 通路在 35 种头颈癌 (HNC) 中的作用。 COX-2 活性还与血管内皮生长因子 (VEGF) mRNA 和蛋白表达相关。肿瘤样本中COX-2 mRNA和蛋白的表达高于正常粘膜。与肿瘤核心和正常粘膜相比，肿瘤前区的 PGE(2) 水平较高（P
We evaluated the role of COX-2 pathway in 35 head and neck cancers (HNCs) by analyzing COX-2 expression and prostaglandin E-2 (PGE(2)) production in relation to tumor angiogenesis and lymph node metastasis. COX-2 activity was also correlated to vascular endothelial growth factor (VEGF) mRNA and protein expression. COX-2 mRNA and protein expression was higher in tumor samples than in normal mucosa. PGE(2) levels were higher in the tumor front zone in comparison with tumor core and normal mucosa (P