Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development
Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development
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DOI：
10.1007/s00441-006-0165-9
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发表时间：
2006-06-01
影响因子：
3.6
通讯作者：
Koike, T
中科院分区：
文献类型：
--
作者：
Shiojiri, N;Niwa, T;Koike, T
肝血管由肝动脉和三种静脉通道（门静脉、窦静脉和肝静脉）组成。本研究通过免疫组织化学分析连接蛋白在胎儿小鼠肝脏血管发育过程中的表达，并特别关注门静脉的发育。在成人肝脏中，connexin37和connexin40在门静脉和肝动脉内皮中表达，而在肝静脉和肝窦内皮中不表达。Connexin43在门静脉间皮细胞和平滑肌细胞中表达。结缔组织蛋白37和结缔组织蛋白40在整个肝脏发育过程中优先表达，包括肝脏原基形成阶段（10.5天或11.5天），尽管结缔组织蛋白37在胎儿期的游离非实质细胞中短暂表达。肝血管系统中各血管的分化可能发生在肝原基形成后不久的早期发育阶段。
Hepatic blood vessels consist of the hepatic artery and three types of venous channels (the portal veins, the sinusoids, and the hepatic veins). This study was undertaken to analyze, by immunohistochemistry, connexin expression throughout the vascular development of the fetal mouse liver with special attention being given to portal vein development. In the adult liver, connexin37 and connexin40 were expressed in the endothelium of the portal vein and hepatic artery, but not in those of the hepatic vein and sinusoids. Connexin43 was expressed in mesothelial cells and smooth muscle cells of the portal veins. The preferential expression of connexin37 and connexin40 in portal veins was seen throughout liver development, including its primordium formation stage (10.5-day or 11.5-day stage), although connexin37 expression was transiently seen in free nonparenchymal cells in fetal stages. The differentiation of each blood vessel in the hepatic vascular system may occur in early developmental stages, soon after hepatic primordium formation.