Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.
复制标题
高剂量率近距离放射治疗治疗严重顽固性掌跖脓疱病的新应用。
DOI：
10.1111/ced.12803
复制
发表时间：
2016
影响因子：
4.1
通讯作者：
Patel,M
中科院分区：
文献类型：
--
作者：
Timerman,D;Devlin,PM;Nambudiri,VE;Wright,NA;Vleugels,RA;Clark,RA;Kupper,TS;Merola,JF;Patel,M
掌跖脓疱病（PPP）是一种慢性脓疱性皮炎的手掌和脚底，这是经常与显着瘙痒和疼痛，往往限制日常活动。我们报告了一例36岁男性重度PPP患者，采用多种药物治疗失败，但采用高剂量率近距离放射治疗后显示出显著改善。近距离放射治疗的优点是在复杂的曲面上提供适形的剂量分布，例如脚和脚踝。我们的观察结果表明，近距离放射治疗可能是重度难治性PPP患者的一种耐受性良好的治疗选择。
Palmoplantar pustulosis (PPP) is a chronic pustular dermatitis of the palms and soles, which is frequently associated with significant pruritus and pain, often limiting daily activities. We present the case of a 36‐year‐old man with severe PPP who had treatment failure with multiple medical therapies but showed marked improvement with high‐dose rate brachytherapy. Brachytherapy has the advantage of providing a conformal dose distribution over complex curved surfaces, such as the foot and ankle. Our observations suggest that brachytherapy may be a well‐tolerated treatment option for patients with severe, refractory PPP.