Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.
Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.
复制标题
结核分枝杆菌 pncA 多态性在 MGIT 中的断点浓度为 100 微克/毫升时不赋予吡嗪酰胺耐药性。
DOI：
10.1128/jcm.01001-15
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发表时间：
2015
影响因子：
9.4
通讯作者：
Posey,JamesE
中科院分区：
文献类型：
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作者：
Whitfield,MichaelG;Warren,RobinM;Streicher,ElizabethM;Sampson,SamanthaL;Sirgel,FrikA;vanHelden,PaulD;Mercante,Alexandra;Willby,Melisa;Hughes,Kelsey;Birkness,Kris;Morlock,Glenn;vanRie,Annelies;Posey,JamesE
结核分枝杆菌cA基因测序允许进行吡嗪酰胺敏感性试验。我们总结了在来自南非和美国疾病控制和预防中心的一组分离株中，在MGIT中吡嗪酰胺敏感性断点为100 μg/ml时不产生耐药性的pncA多态性的数据。
Sequencing of the Mycobacterium tuberculosispncAgene allows for pyrazinamide susceptibility testing. We summarize data onpncApolymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.