The commonest glomerulonephritis in the world: IgA nephropathy.
The commonest glomerulonephritis in the world: IgA nephropathy.
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DOI：
10.1093/oxfordjournals.qjmed.a068143
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发表时间：
1987-09
期刊：
影响因子：
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通讯作者：
Giuseppe D'Amico
中科院分区：
文献类型：
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作者：
Giuseppe D'Amico
在过去的15年中，在许多疾病中都发现了弥漫性肾小球内的IgA系膜沉积，其特征是粘膜表面的改变，与IgA的过量产生和/或清除受损有关。特发性IgA系膜肾病最初由Berger和Hinglais于1968年描述，直到最近才引起肾病学家的注意，因为它是世界上许多国家最常见的原发性肾小球疾病，并且它可以有一个渐进的过程，在不同的时期导致终末期肾衰竭。有两个主要原因可以解释为什么这种疾病长期被忽视：(1)它的诊断是基于免疫组织学检查，直到60年代末才成为大多数机构接受的常规检查；(2)该病一半以上患者的特点是几乎没有临床症状，因此许多肾病学家认为没有必要进行活检。
Mesangial deposits of IgA, diffuse in all glomeruli, have been found in the last 15 years in a great number of diseases, characterized by changes in mucosal surfaces, associated with hyperproduction and/or impaired removal of IgA. The idiopathic type of IgA mesangial nephropathy, first described by Berger and Hinglais in 1968 [1], has only recently attracted the attention of nephrologists, since it is becoming evident that it is the most frequent primary glomerular disease in many countries throughout the world and that it can have a progressive course, leading over variable periods to end-stage renal failure. Two main reasons can explain why this disease has long been neglected:(1) its diagnosis is based on immunohistological examination which became an accepted routine in the majority of institutions only at the end of the 60s;(2) the disease is characterized in more than half of patients by almost no clinical symptoms, so that biopsy is considered unnecessary by many nephrologists.