Dietary patterns and breast cancer risk in a prospective Japanese study
Dietary patterns and breast cancer risk in a prospective Japanese study
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DOI：
10.1007/s12282-016-0689-0
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发表时间：
2017-01-01
期刊：
影响因子：
4
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
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作者：
Kojima, Reiji;Okada, Emiko;Tamakoshi, Akiko
饮食模式与乳腺癌之间的关系一直不一致。本研究调查了日本协作队列研究中23，172名女性的饮食模式与患乳腺癌风险之间的关系，其中包括在中位16.9年随访期间诊断出的119例乳腺癌。通过因子分析获得饮食模式，并使用考克斯比例模型估计乳腺癌发病率的风险比（HR）和95%置信区间（95%CI）。（蔬菜、土豆、紫菜、豆腐、水果、鲜鱼、鸡蛋、味噌汤）;“动物食品”（肉类、油炸食品、油炸蔬菜、鱼酱及盐腌鱼）及“奶制品”（牛奶、奶制品、水果、咖啡及茶）。在调整潜在的混杂因素后，蔬菜和乳制品模式与乳腺癌风险无显著相关性。然而，动物性食物模式与绝经前妇女乳腺癌发病风险降低显著相关，第二个三分位数的HR为0.47。（95% CI 0.22-1.00）和HR 0.42（第三个三分位数）（95% CI 0.18-0.93），与底部三分位数相比我们发现蔬菜和乳制品饮食模式与乳腺癌风险之间没有显著关联;然而，动物产品饮食可能会降低绝经前日本妇女患乳腺癌的风险。
The association between dietary patterns and breast cancer has been inconsistent.This study examined associations between dietary patterns and risk of developing breast cancer among 23,172 women from the Japan Collaborative Cohort Study, including 119 incidences of breast cancer diagnosed during a median 16.9-year follow-up period. Factor analysis was conducted to obtain dietary patterns, and Cox proportional models were used to estimate hazard ratios (HR) and 95 % confidence intervals (95 % CI) for breast cancer morbidity.Three dietary patterns were identified: ''vegetable pattern'' (vegetables, potatoes, seaweed, tofu, fruits, fresh fish, eggs, and miso soup); ''animal food pattern'' (meat, deep-fried foods, fried vegetables, fish paste and salt-preserved fish); and "dairy product pattern'' (milk, dairy products, fruits, coffee and tea). After adjusting for potential confounders, the vegetable and dairy product patterns were not significantly associated with risk of breast cancer. However, the animal food pattern was significantly associated with a decreased risk of breast cancer morbidity among premenopausal women by HR 0.47 for the 2nd tertile (95 % CI 0.22-1.00) and HR 0.42 for the 3rd tertile (95 % CI 0.18-0.93), compared with the bottom tertile (p for trend 0.04).We found no significant association between the vegetable and dairy product dietary patterns and breast cancer risk; however, an animal product diet may reduce risk of breast cancer among premenopausal Japanese women.