Improved detection of lung cancer arising in diffuse lung diseases on chest radiographs using temporal subtraction
Improved detection of lung cancer arising in diffuse lung diseases on chest radiographs using temporal subtraction
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DOI：
10.1016/s1076-6332(03)00820-1
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发表时间：
2004-05-01
影响因子：
4.8
通讯作者：
Katsuragawa, S
中科院分区：
文献类型：
--
作者：
Okazaki, H;Nakamura, K;Katsuragawa, S
理由和目标。本研究的目的是评估时间减影检测肺癌的尘肺，特发性肺纤维化，肺气肿。材料和方法。评估了15例弥漫性肺部疾病引起的肺癌病例，其中包括3例尘肺病、6例特发性肺纤维化和6例肺气肿。手术或经支气管肺活检病理证实。既往和当前X线片之间的平均间隔为356天（范围，31-947天）。所有胸部X线片均采用计算机X线摄影系统获得，时间减影图像通过非线性图像扭曲技术从当前图像中减去先前图像而产生。通过观察者行为研究和受试者操作特征分析评价时间减影图像的效果。与未使用时间减影的患者相比，使用时间减影的患者的平均观察结果（Az = 0.857，P <0.0001）有显著改善。时间减影技术可用于检测尘肺、特发性肺纤维化和肺气肿引起的肺癌。
Rationale and Objectives. The purpose of this study was to evaluate the usefulness of temporal subtraction for the detection of lung cancer arising in pneumoconiosis, idiopathic pulmonary fibrosis, and pulmonary emphysema.Materials and Methods. Fifteen cases of lung cancer arising in diffuse lung diseases, including three cases of pneumoconiosis, six of idiopathic pulmonary fibrosis, and six of pulmonary emphysema, were evaluated. Pathologic proof was obtained by surgery or transbronchial lung biopsy. The average interval between previous and current radiographs was 356 days (range, 31-947 days). All chest radiographs were obtained with a computed radiography system, and temporal subtraction images were produced by subtracting of a previous image from a current one with a nonlinear image-warping technique. The effect of the temporal subtraction image was evaluated by observer performance study with receiver operating characteristic analysis.Results. The average observer performance with temporal subtraction was significantly improved (Az = 0.935) compared with that without temporal subtraction (Az = 0.857, P < .0001).Conclusion. The temporal subtraction technique is useful for the detection of lung cancer arising in pneumoconiosis, idiopathic pulmonary fibrosis, and pulmonary emphysema.