Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
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DOI：
10.1016/j.yjmcc.2022.03.007
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发表时间：
2022-06
影响因子：
5
通讯作者：
Davenport AP
中科院分区：
文献类型：
--
作者：
Abraham GR;Kuc RE;Althage M;Greasley PJ;Ambery P;Maguire JJ;Wilkinson IB;Hoole SP;Cheriyan J;Davenport AP
病毒诱导的内皮细胞失调是严重Covid-19感染的公认特征。内皮素-1（ET-1）是内皮细胞中表达最高的肽，是一种有效的血管收缩剂，因此代表了潜在的治疗靶点。在一个根据疾病临床严重程度分层的194名Covid-19患者队列中测量了ET-1血浆水平。住院患者，包括那些谁死了，发展急性心肌或肾损伤，有显着升高的ET-1血浆水平在急性感染期。结果支持内皮素受体拮抗剂可能为某些Covid-19患者提供临床获益的假设。内皮功能失调是严重Covid-19感染的一个特征。内皮肽ET-1是一个潜在的治疗靶点。较高的循环ET-1水平与更严重的感染有关。内皮素受体拮抗剂可能在Covid-19中具有临床益处。
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients. Dysregulation of endothelial function is a feature of severe Covid-19 infection. The endothelial peptide, ET-1 is a potential therapeutic target. Higher circulating ET-1 levels are associated with more severe infection. Endothelin receptor antagonists may be of clinical benefit in Covid-19.
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影响因子：
21.1
作者：
Davenport AP;Hyndman KA;Dhaun N;Southan C;Kohan DE;Pollock JS;Pollock DM;Webb DJ;Maguire JJ
通讯作者：
Maguire JJ
影响因子：
3.2
作者：
Fisk M;Althage M;Moosmang S;Greasley PJ;Cope AP;Jayne DR;Galloway J;Hall F;Wilkinson IB;Ambery P;Cheriyan J
通讯作者：
Cheriyan J
DOI：
10.5339/gcsp.2014.29
发表时间：
2014
期刊：
Global cardiology science & practice
影响因子：
--
作者：
Chester AH;Yacoub MH
通讯作者：
Yacoub MH
DOI：
10.1016/s0735-1097(99)00224-7
发表时间：
1999-08-01
影响因子：
24
作者：
Cox, ID;Botker, HE;Kaski, JC
通讯作者：
Kaski, JC
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny