Long chain polyunsaturated fatty acid supplementation in infancy increases length- and weight-for-age but not BMI to 6 years when controlling for effects of maternal smoking.
Long chain polyunsaturated fatty acid supplementation in infancy increases length- and weight-for-age but not BMI to 6 years when controlling for effects of maternal smoking.
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DOI：
10.1016/j.plefa.2015.04.001
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Carlson SE
中科院分区：
文献类型：
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作者：
Currie LM;Tolley EA;Thodosoff JM;Kerling EH;Sullivan DK;Colombo J;Carlson SE
长链多不饱和脂肪酸(LCPUFA)被添加到婴儿配方奶粉中，但其对儿童长期生长的影响仍在研究中。我们评估了婴儿时期饲喂含LCPUFA配方奶粉(n=54)和对照配方奶粉(n=15)对婴儿出生6岁后生长的影响。使用SAS®混合程序开发的单独模型来描述生长情况，其中包括母亲吸烟史和性别。与喂食对照配方奶粉的儿童相比，食用LCPUFA配方奶粉的儿童从出生到6岁的身长/身高和体重百分位数较高，但体重指数(BMI)百分位数没有增加。母亲吸烟预示着较低的身高(2-6岁)、较高的身长体重(出生-18个月)和BMI百分位数(2-6岁)，独立于LCPUFA的影响。性别与LCPUFA对身高的影响以及吸烟与BMI的关系存在交互作用，对男孩的影响更大。能量摄入不能解释生长差异。相对较小的对照样本是一个限制。
Long chain polyunsaturated fatty acids (LCPUFA) are added to infant formula but their effect on long-term growth of children is under studied. We evaluated the effects of feeding LCPUFA-supplemented formula (n=54) compared to control formula (n=15) throughout infancy on growth from birth-6 years. Growth was described using separate models developed with the MIXED procedure of SAS® that included maternal smoking history and gender. Compared to children fed control formula, children who consumed LCPUFA supplemented formula had higher length-/stature-/and weight-for-age percentiles but not body mass index (BMI) percentile from birth to 6 years. Maternal smoking predicted lower stature (2-6 years), higher weight-for-length (birth-18 months) and BMI percentile (2-6 years) independent of LCPUFA effects. Gender interacted with the effect of LCPUFA on stature, and the relationship between smoking and BMI, with a larger effect for boys. Energy intake did not explain growth differences. A relatively small control sample is a limitation.