IL-10 and ARG-1 concentrations in bone marrow and peripheral blood of metastatic neuroblastoma patients do not associate with clinical outcome.
IL-10 and ARG-1 concentrations in bone marrow and peripheral blood of metastatic neuroblastoma patients do not associate with clinical outcome.
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DOI：
10.1155/2015/718975
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发表时间：
2015
影响因子：
4.1
通讯作者：
Corrias MV
中科院分区：
文献类型：
--
作者：
Morandi F;Croce M;Cangemi G;Barco S;Rigo V;Carlini B;Amoroso L;Pistoia V;Ferrini S;Corrias MV
分别作为调节性T细胞（Treg）和巨噬细胞的标志物的免疫抑制分子IL-10和ARG-1以及FOXP 3和CD 163的表达在诊断时从患有转移性神经母细胞瘤（NB）的患者收集的骨髓（BM）和外周血（PB）样品中进行评价。测量IL-10和ARG-1血浆浓度，并检验每个参数与患者结局的相关性。还测定了免疫抑制性Treg和1型调节（Tr 1）细胞的百分比。在BM和PB样本中，转移性NB患者中IL-10 mRNA表达高于对照组。IL-10血浆浓度在NB患者中较高，与分期无关。IL-10表达和IL-10血浆浓度均与患者生存率无显著相关性。在转移性NB患者的PB样本中，ARG-1和CD 163表达高于对照组，但其表达与生存无关。此外，ARG-1血浆浓度低于对照组，且与患者结局无关。最后，在转移性NB患者中，循环Treg的百分比高于对照组，而Tr 1细胞的百分比较低。总之，尽管IL-10浓度和Treg百分比增加，但它们对转移性NB的自然史的贡献似乎不确定。
The expression of the immunosuppressive molecules IL-10 and arginase 1 (ARG-1), and of FOXP3 and CD163, as markers of regulatory T cells (Treg) and macrophages, respectively, was evaluated in bone marrow (BM) and peripheral blood (PB) samples collected at diagnosis from patients with metastatic neuroblastoma (NB). IL-10 and ARG-1 plasma concentrations were measured and the association of each parameter with patients' outcome was tested. The percentages of immunosuppressive Treg and type-1 regulatory (Tr1) cells were also determined. In both BM and PB samples, IL-10 mRNA expression was higher in metastatic NB patients than in controls. IL-10 plasma concentration was higher in patients with NB regardless of stage. Neither IL-10 expression nor IL-10 plasma concentration significantly associated with patient survival. In PB samples from metastatic NB patients, ARG-1 and CD163 expression was higher than in controls but their expression did not associate with survival. Moreover, ARG-1 plasma concentration was lower than in controls, and no association with patient outcome was found. Finally, in metastatic NB patients, the percentage of circulating Treg was higher than in controls, whereas that of Tr1 cells was lower. In conclusion, although IL-10 concentration and Treg percentage were increased, their contribution to the natural history of metastatic NB appears uncertain.
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影响因子：
10.3
作者：
Asgharzadeh, Shahab;Pique-Regi, Roger;Seeger, Robert C.
通讯作者：
Seeger, Robert C.
影响因子：
6.4
作者：
Croce, Michela;Corrias, Maria Valeria;Ferrini, Silvano
通讯作者：
Ferrini, Silvano
影响因子：
7.4
作者：
Gowda, Madhu;Godder, Kamar;Manjili, Masoud H.
通讯作者：
Manjili, Masoud H.
影响因子：
11.2
作者：
Bergmann, Christoph;Strauss, Laura;Whiteside, Theresa L.
通讯作者：
Whiteside, Theresa L.
影响因子：
45.3
作者：
BRODEUR, GM;PRITCHARD, J;VOUTE, PA
通讯作者：
VOUTE, PA