Regenerative nanomedicine: current perspectives and future directions.
Regenerative nanomedicine: current perspectives and future directions.
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DOI：
10.2147/ijn.s45332
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发表时间：
2014
影响因子：
8
通讯作者：
RoyChoudhury S
中科院分区：
文献类型：
--
作者：
Chaudhury K;Kumar V;Kandasamy J;RoyChoudhury S
近年来，纳米技术大大加速了再生医学的发展。纳米技术在再生医学中的应用已经彻底改变了移植物和支架的设计，这导致了新的移植物/支架系统具有显著增强的细胞和组织再生特性。由于生物系统中的细胞-细胞和细胞-基质相互作用发生在纳米级水平，因此纳米技术的应用在以更期望的方式修饰细胞功能和/或基质功能以模拟天然组织/器官方面具有优势。在这篇综述中，我们重点介绍了基于纳米技术的再生医学的最新进展和趋势，并讨论了单个器官系统，包括骨，软骨，神经，皮肤，牙齿，心肌，肝脏和眼睛。最近的研究是有关各种类型的纳米结构支架的设计和纳米材料纳入矩阵的报告。我们还记录了报告，其中比较了这些材料和基质的生物相容性和支持受损组织的有效性。除了最近的发展，未来的方向和可能的挑战，在翻译的结果从板凳到床边概述。
Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.