Breast cancer in relation to the occurrence and time of induced and spontaneous abortion.
Breast cancer in relation to the occurrence and time of induced and spontaneous abortion.
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乳腺癌与人工流产和自然流产的发生和时间的关系。
DOI：
10.1093/oxfordjournals.aje.a114901
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发表时间：
1988
影响因子：
5
通讯作者：
S. Shapiro
中科院分区：
文献类型：
--
作者：
L. Rosenberg;J. Palmer;D. Kaufman;B. Strom;D. Schottenfeld;S. Shapiro
作者评估了妊娠前六个月的人工流产或自然流产是否会增加患乳腺癌的风险，特别是如果发生在第一足月妊娠之前。研究数据来自一项70岁以下女性的病例对照研究：3200例乳腺癌患者与4844例非恶性非妇科疾病患者进行比较。在未产和已产妇女中，乳腺癌的风险与人工流产或自然流产的次数无关。在排除所有确定的潜在混杂因素后，估计未生育妇女人工流产相对于从未怀孕妇女的相对风险为1.3(95%置信区间（CI） 0.8-2.2)，而自然流产的相应估计为0.9 （95% CI 0.5-1.5）。在已产妇女中，相对于从未有过任何类型的流产，人工流产的估计相对风险为1.2 (95% CI 0.9-1.6)，自然流产的估计相对风险为0.9 （95% CI 0.8-1.0）。流产的时间几乎没有影响：第一足月前人工流产的相对风险估计为0.9 (95% CI 0.5-1.4)，第一足月后首次发生人工流产的相对风险估计为1.4 (95% CI 1.0-1.9)，第一足月前自然流产的相对风险估计为0.9 (95% CI 0.7-1.2)，第一足月后首次发生自然流产的相对风险估计为0.9 （95% CI 0.7-1.0）。在40岁以下的女性中，类似的结果也很明显，其中人工流产的频率相对较高。这些数据表明，无论是在第一次足月分娩之前还是之后，堕胎对患乳腺癌的风险没有实质性影响。
The authors evaluated whether an induced or spontaneous abortion during the first six months of gestation, particularly if it occurs before the first term pregnancy, increases the risk of breast cancer. Data from a case-control study of women under 70 years of age were used: 3,200 cases of breast cancer were compared with 4,844 controls with nonmalignant nongynecologic conditions. Among both nulliparous and parous women, the risk of breast cancer was not related to the number of induced or spontaneous abortions. After allowance for all identified potential confounding factors, the estimated relative risk for nulliparous women with an induced abortion relative to those who had never been pregnant was 1.3 (95% confidence interval (CI) 0.8-2.2), and for spontaneous abortion, the corresponding estimate was 0.9 (95% CI 0.5-1.5). Among parous women, the estimated relative risks were 1.2 (95% CI 0.9-1.6) for an induced abortion and 0.9 (95% CI 0.8-1.0) for a spontaneous abortion, relative to never having had an abortion of any type. The time of the abortion had little effect: The relative risk estimates were 0.9 (95% CI 0.5-1.4) for induced abortion before the first term birth, 1.4 (95% CI 1.0-1.9) for induced abortion first occurring after the first term birth, 0.9 (95% CI 0.7-1.2) for spontaneous abortion before the first term birth, and 0.9 (95% CI 0.7-1.0) for spontaneous abortion first occurring after the first term birth. Similar results were evident for women under age 40, among whom the frequency of induced abortion was relatively high. These data suggest that the risk of breast cancer is not materially affected by abortion, regardless of whether it occurs before or after the first term birth.