Inflammation in Atherosclerosis
Inflammation in Atherosclerosis
复制标题
DOI：
10.1002/9783527692156.ch49
复制
发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
M. Lauterbach;L. Labzin;E. Latz
中科院分区：
文献类型：
--
作者：
M. Lauterbach;L. Labzin;E. Latz
动脉粥样硬化是一种心血管系统疾病，其临床表现占全球死亡人数的相当大一部分。虽然发病机制是由动脉血管和脂蛋白代谢缺陷引发的，但伴随的无菌性炎症是疾病进展的基本方面。在过去的15年中，积累了大量关于动脉粥样硬化背景下炎症触发因子、受体和效应程序的证据。本章旨在概述驱动动脉粥样硬化形成的无菌炎症过程，重点是先天免疫系统如何在疾病进展过程中感知稳态失衡。此外，我们将说明药物和饮食因素如何调节动脉粥样硬化中的炎症。
Atherosclerosis is a disease of the cardiovascular system and its clinical manifestations account for a considerable portion of deaths worldwide. While pathogenesis is initiated by defects in the arterial vasculature and in lipoprotein metabolism, the accompanying sterile inflammation is a fundamental aspect of disease progression. Over the course of the last 15 years, a vast body of evidence on inflammatory triggers, receptors, and effector programs in the context of atherosclerosis has accumulated. This chapter aims to give an overview of the sterile inflammatory processes that drive atherogenesis, focusing on how the innate immune system senses homeostatic imbalance during disease progression. Furthermore, we will illustrate how pharmacological agents and dietary factors can modulate inflammation in atherosclerosis.