Reactive oxygen species a double-edged sword for mesothelioma.
Reactive oxygen species a double-edged sword for mesothelioma.
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DOI：
10.18632/oncotarget.4253
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发表时间：
2015-07-10
期刊：
影响因子：
--
通讯作者：
Galati R
中科院分区：
文献类型：
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作者：
Benedetti S;Nuvoli B;Catalani S;Galati R
众所周知，氧化应激可导致慢性炎症，而慢性炎症又可介导包括癌症在内的大多数慢性疾病。氧化剂与石棉石和石棉石的活性有关，这是与间皮瘤的发生有关的最强大的石棉类型。目前，间皮瘤的发病率正在上升，估计表明，在西方世界，间皮瘤的发病率将在未来10-15年内达到峰值，而在日本，预计到40年后才会达到峰值。虽然世界上许多国家已禁止使用石棉，但石棉的生产和潜在危险的接触仍然存在，当地间皮瘤的发病率很高。今天，一种新的人造材料——碳纳米管——引起了人们的关注；碳纳米管可能表现出“石棉样”致病性，具有间皮瘤诱导潜能。碳纳米管产生的活性氧最多。氧化应激如何激活炎症途径，导致正常细胞向肿瘤细胞转化，肿瘤细胞存活、增殖、侵袭、血管生成、化疗耐药和放射耐药，是本综述的目的。
It is well known that oxidative stress can lead to chronic inflammation which, in turn, could mediate most chronic diseases including cancer. Oxidants have been implicated in the activity of crocidolite and amosite, the most powerful types of asbestos associated to the occurrence of mesothelioma. Currently rates of mesothelioma are rising and estimates indicate that the incidence of mesothelioma will peak within the next 10–15 years in the western world, while in Japan the peak is predicted not to occur until 40 years from now. Although the use of asbestos has been banned in many countries around the world, production of and the potentially hazardous exposure to asbestos is still present with locally high incidences of mesothelioma. Today a new man-made material, carbon nanotubes, has arisen as a concern; carbon nanotubes may display ‘asbestos-like’ pathogenicity with mesothelioma induction potential. Carbon nanotubes resulted in the greatest reactive oxygen species generation. How oxidative stress activates inflammatory pathways leading to the transformation of a normal cell to a tumor cell, to tumor cell survival, proliferation, invasion, angiogenesis, chemoresistance, and radioresistance, is the aim of this review.