Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner.
Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner.
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软组织变化以空间相关的方式影响 HR-pQCT 密度测量。
DOI：
10.1016/j.bone.2020.115505
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发表时间：
2020
期刊：
影响因子：
4.1
通讯作者：
Kazakia,Galateia
中科院分区：
文献类型：
--
作者：
Wu,Po-Hung;Gupta,Tanvi;Chang,Hanling;Petrenko,Dimitry;Schafer,Anne;Kazakia,Galateia
肥胖症治疗后的体重显著减轻会破坏骨代谢，增加骨转换和骨折发生率。高分辨率外周定量计算机断层扫描（HR-pQCT）广泛用于骨骼健康评估研究，以提供无创骨参数测量（例如体积骨矿物质密度（vBMD）），辐射暴露最小。然而，研究组之间的身体组成变化或经历显著体重变化的个体内的纵向变化将在HR-pQCT数据中产生伪影和误差。本研究的目的是确定这些文物的影响vBMD.MethodsWe测量设计了一个定制的羟基磷灰石（HA）聚合物幻影周围的层可重复使用的凝胶包和氢化脂肪模仿胫骨远端和周围的瘦和脂肪组织。四种不同厚度的脂肪被用来模拟日益超重的个体的软组织。然后，我们评估了软组织厚度的变化如何影响图像质量和vBMD定量的总，小梁和皮质骨隔间。基于这些数据，我们应用了数据校正先前获得的临床数据在一个队列的胃旁路patients.ResultsIn的幻影测量，总，小梁，皮质vBMD增加软组织厚度降低。软组织厚度对vBMD的影响因解剖象限而异。当应用软组织数据校正的一组临床数据，我们发现，减肥手术后的软组织减少可能会导致临床上显着低估的骨丢失的纵向data.ConclusionHR-pQCT为基础的vBMD测量精度的影响，在皮质compartment.ConclusionHR-pQCT为基础的vBMD测量精度是由软组织厚度和空间不均匀。我们的研究结果表明，在HR-pQCT研究中必须考虑软组织厚度的变化，特别是在招募不同身体成分的队列研究或纵向体重变化研究中。
ObjectiveSignificant weight loss following treatments for obesity undermines bone metabolism and increases bone turnover and fracture incidence. High resolution peripheral quantitative computed tomography (HR-pQCT) is widely used in skeletal heath assessment research to provide noninvasive bone parameter measurement (e.g. volumetric bone mineral density (vBMD)) with minimal radiation exposure. However, variation in body composition among study groups or longitudinal variations within individuals undergoing significant weight change will generate artifacts and errors in HR-pQCT data. The purpose of this study is to determine the influence of these artifacts on the measurement of vBMD.MethodsWe designed a custom-made hydroxyapatite (HA)-polymer phantom surrounded by layers of reusable gel pack and hydrogenated fat to mimic the distal tibia and the surrounding lean and fat tissue. Four different thicknesses of fat were used to mimic the soft tissue of increasingly overweight individuals. We then evaluated how a change in soft tissue thickness influenced image quality and vBMD quantification within total, trabecular, and cortical bone compartments. Based on these data, we applied a data correction to previously acquired clinical data in a cohort of gastric bypass patients.ResultsIn the phantom measurements, total, trabecular, and cortical vBMD increased as soft tissue thickness decreased. The impact of soft tissue thickness on vBMD varied by anatomic quadrant. When applying the soft tissue data correction to a set of clinical data, we found that soft tissue reduction following bariatric surgery can lead to a clinically significant underestimation of bone loss in longitudinal data, and that the effect is most severe in the cortical compartment.ConclusionHR-pQCT-based vBMD measurement accuracy is influenced by soft tissue thickness and is spatially inhomogeneous. Our results suggest that variations in soft tissue thickness must be considered in HR-pQCT studies, particularly in studies enrolling cohorts with differing body composition or in studies of longitudinal weight change.