Expression of Thy-1 antigen by murine epidermal cells.
Expression of Thy-1 antigen by murine epidermal cells.
复制标题
小鼠表皮细胞表达 Thy-1 抗原。
DOI：
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发表时间：
1983
影响因子：
6.5
通讯作者：
G. Stingl
中科院分区：
文献类型：
--
作者：
E. Tschachler;G. Schuler;J. Hutterer;H. Leibl;K. Wolff;G. Stingl
我们报告了小鼠表皮内细胞群的出现，根据形态和表面特性标准，该细胞群与迄今为止已知的所有其他表皮细胞类型不同。这些以前未被识别的细胞均匀分布在表皮内，呈现出主要的树突状形状，呈现分叶状核，含有大量波形蛋白型中等大小的丝，但缺乏桥粒、黑素体、默克尔细胞颗粒和伯贝克颗粒。与黑素细胞相反，这些细胞无法表现出酪氨酸酶活性。表面标志物分析显示这些细胞一致表达 Thy-1 抗原并缺乏 I-A 和 I-E/C 抗原特异性。这些 Thy-1 携带细胞的主要部分与 Ly-5 决定簇的单克隆抗体发生反应，而尝试证明 Lyt-1,2,3 抗原始终产生阴性结果。这些发现强烈表明 Thy-1+ 表皮细胞起源于骨髓；然而，它们与造血分化途径不同成员的确切关系仍有待确定。
We report on the occurrence of a cell population within the murine epidermis which, by both morphologic and surface property criteria, is distinct from all other epidermal cell types known so far. These previously unrecognized cells are evenly distributed within the epidermis, display a primarily dendritic shape, exhibit a lobulated nucleus, contain large amounts of vimentin type intermediate-sized filaments, but lack desmosomes, melanosomes, Merkel cell granules, and Birbeck granules. As opposed to melanocytes, these cells fail to display tyrosinase activity. Surface marker analysis reveals these cells to uniformly express the Thy-1 antigen and to lack I-A and I-E/C antigen specificities. A major portion of these Thy-1-bearing cells are reactive with a monoclonal antibody to the Ly-5 determinant whereas attempts to demonstrate Lyt-1,2,3 antigens consistently yield negative results. These findings strongly suggest that Thy-1+ epidermal cells originate from the bone marrow; however, their precise relationship to distinct members of the hemopoietic differentiation pathway remains to be established.
Thy-1 抗原的表达不限于小鼠造血细胞培养物中的 T 细胞。
DOI：
10.1073/pnas.79.13.4161
发表时间：
1982
影响因子：
11.1
作者：
Schrader,JW;Battye,F;Scollay,R
通讯作者：
Scollay,R