The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta.
The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta.
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DOI：
10.1021/ol070735
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发表时间：
2007-05
期刊：
影响因子：
5.2
通讯作者：
S. Yin;Xiao-Ning Wang;C. Fan;S. Liao;J. Yue
中科院分区：
文献类型：
--
作者：
S. Yin;Xiao-Ning Wang;C. Fan;S. Liao;J. Yue
Walsuronoid A (1), a limonoid featuring an unprecedented 3,4-peroxide-bridged A-seco skeleton, together with walsuronoids B (2) and C (3) possessing a rare 18(13-->14)-abeo-limonoid skeleton, was isolated from Walsura robusta. The structures were elucidated by spectroscopic analysis and chemical correlation, and that of 1 was confirmed by single-crystal X-ray diffraction. Biosynthetic pathway of 2 and 3 was proposed and was chemically mimicked. Compounds 1 and 2 showed weak antimalarial activity.
