The Role of Elongin BC-Containing Ubiquitin Ligases.
The Role of Elongin BC-Containing Ubiquitin Ligases.
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DOI：
10.3389/fonc.2012.00010
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发表时间：
2012
影响因子：
4.7
通讯作者：
Kamura T
中科院分区：
文献类型：
--
作者：
Okumura F;Matsuzaki M;Nakatsukasa K;Kamura T
Elongin复合物最初被鉴定为RNA聚合酶II的正调控因子，由一个转录活性亚基（A）和两个调控亚基（B和C）组成。延伸蛋白BC复合物增强延伸蛋白A的转录活性。“经典的”含SOCS盒的蛋白质与Elongin BC复合物相互作用并具有泛素连接酶活性。它们还与支架蛋白Cullin（Cul）和RING结构域蛋白Rbx相互作用，因此是Cullin RING连接酶（CRL）超家族的成员。延伸蛋白BC复合物充当连接Cul和SOCS盒蛋白的衔接子。最近的研究表明，经典的SOCS盒蛋白可以进一步分为两类，Cul 2-和Cul 5-型蛋白。经典的含SOCS盒的蛋白质pVHL现在被分类为Cul 2型蛋白质。含有CRL家族的Elongin BC复合物现在被认为是两种不同的蛋白质组装体，它们在调节多种细胞过程如肿瘤发生、信号转导、细胞运动和分化中起重要作用。
The Elongin complex was originally identified as a positive regulator of RNA polymerase II and is composed of a transcriptionally active subunit (A) and two regulatory subunits (B and C). The Elongin BC complex enhances the transcriptional activity of Elongin A. “Classical” SOCS box-containing proteins interact with the Elongin BC complex and have ubiquitin ligase activity. They also interact with the scaffold protein Cullin (Cul) and the RING domain protein Rbx and thereby are members of the Cullin RING ligase (CRL) superfamily. The Elongin BC complex acts as an adaptor connecting Cul and SOCS box proteins. Recently, it was demonstrated that classical SOCS box proteins can be further divided into two groups, Cul2- and Cul5-type proteins. The classical SOCS box-containing protein pVHL is now classified as a Cul2-type protein. The Elongin BC complex containing CRL family is now considered two distinct protein assemblies, which play an important role in regulating a variety of cellular processes such as tumorigenesis, signal transduction, cell motility, and differentiation.