An improved version of the DNA methylation database (MethDB)
An improved version of the DNA methylation database (MethDB)
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DOI：
10.1093/nar/gkg093
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Grunau, C
中科院分区：
文献类型：
--
作者：
Amoreira, C;Hindermann, W;Grunau, C
胞嘧啶甲基化是原核和真核基因组的特征。对于后者，它对于生物体的健康发育是必不可少的，并且 5-甲基胞嘧啶 (5mC) 分布不受控制的变化与严重疾病，特别是癌症有关。人们对 DNA 甲基化的科学兴趣日益浓厚，产生了大量有关这种表观遗传现象的数据。为了使这些数据易于获取，我们建立了专门的数据库。 DNA甲基化数据库（MethDB）是目前唯一的DNA甲基化公共数据库（http://www.methdb.net）。这个不断增长的数据库已成为 DNA 甲基化研究领域的关键资源。该数据库目前包含 46 个物种、160 个组织和 72 个表型的甲基化模式、概况和总甲基化含量数据，这些数据来自总共 6667 个实验（截至 2002 年 9 月 4 日）。大约 14% 的数据尚未在其他地方发布。这些数据可以方便地搜索并以不同的方式表示。最近，我们提供了一个在线提交工具，允许科学公众直接将新数据输入 MethDB。
Cytosine methylation is a characteristic property of prokaryotic and eukaryotic genomes. In the latter, it is indispensable for a healthy development of the organism and uncontrolled changes in the distribution of 5-methylcytosine (5mC) have been linked to severe disorders, in particular cancer. The growing scientific interest in DNA methylation has led to a considerable amount of data about this epigenetic phenomenon. In order to make these data readily available, we have established a dedicated database. The DNA Methylation database (MethDB) is currently the only public database for DNA methylation (http://www.methdb.net). This constantly growing database has become a key resource in the field of DNA methylation research. The database contains currently methylation patterns, profiles and total methylation content data for 46 species, 160 tissues and 72 phenotypes coming from a total of 6667 experiments (as of September 4, 2002). About 14% of the data have not been published elsewhere. These data can be conveniently searched and represented in different ways. Recently, we have included an on-line submission tool that permits the scientific public to directly enter new data into MethDB.