Food-Dependent Exercise-Induced Anaphylaxis-Importance of Omega-5 Gliadin and HMW-Glutenin as Causative Antigens for Wheat-Dependent Exercise-Induced Anaphylaxis
Food-Dependent Exercise-Induced Anaphylaxis-Importance of Omega-5 Gliadin and HMW-Glutenin as Causative Antigens for Wheat-Dependent Exercise-Induced Anaphylaxis
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DOI：
10.2332/allergolint.09-rai-0125
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发表时间：
2009-12-01
影响因子：
6.8
通讯作者：
Tanaka, Akira
中科院分区：
文献类型：
--
作者：
Morita, Eishin;Matsuo, Hiroaki;Tanaka, Akira
食物依赖型运动性过敏反应(FDEIA)是一种特殊形式的食物过敏，仅摄入食物不会引起任何症状。然而，当在摄入致病食物后添加运动或服用阿司匹林等触发因素时，就会引发过敏症状。在日本，最常见的致病食品是小麦。运动和摄入阿司匹林的触发因素促进了过敏原从胃肠道的吸收，导致小麦依赖型运动诱导过敏反应(WDEIA)患者出现过敏症状。使用纯化的小麦蛋白分析显示，大约80%的WDEIA患者对omega-5醇溶蛋白有IgE反应，其余的患者对高分子量谷蛋白(HMW-GS)有反应。与小麦常规诊断系统相比，同时测定Omega-5醇溶蛋白和高分子量谷蛋白的特异性IgE在诊断WDEIA中具有很高的实用价值。
Food-dependent exercise-induced anaphylaxis (FDEIA) is a special form of food allergy where a food-intake alone does not induce any symptoms. However, allergic symptoms are elicited when triggering factors such as exercise or aspirin-intake are added after ingestion of the causative food. The most frequent causative foodstuff in Japan is wheat. The triggering factors, both exercise and aspirin-intake, facilitate allergen absorption from the gastrointestinal tract, resulting in allergic symptoms in the patients with wheat-dependent exercise-induced anaphylaxis (WDEIA). Analysis using purified wheat proteins revealed that approximately 80% of the patients with WDEIA have IgE reacting to omega-5 gliadin and the remaining of the patients to high molecular weight glutenin (HMW-glutenin). Simultaneous measurement of specific IgE to omega-5 gliadin and HMW-glutenin was found to be highly useful in diagnosing WDEIA compared with the routine diagnostic system for wheat.