The Interdependence between Schistosome Transmission and Protective Immunity.
The Interdependence between Schistosome Transmission and Protective Immunity.
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DOI：
10.3390/tropicalmed2030042
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发表时间：
2017-08-23
影响因子：
2.9
通讯作者：
Wilson S
中科院分区：
文献类型：
--
作者：
Oettle RC;Wilson S
用于控制血吸虫病的大规模药物管理（MDA）可能会通过被动疫苗接种和降低局部传播强度相结合来影响传播动态。这在免疫现象学模型和 MDA 的影响中得到了体现，但这些模型中的免疫参数并未通过反映对再感染的保护性免疫力的经验数据进行验证。有重要的经验证据支持 IgE 在获得性保护性免疫中的作用。这被认为是延迟伴随免疫的一种形式，至少部分是由对皮层过敏原样 (TAL) 蛋白家族的保护性 IgE 反应驱动的。关于保护性免疫反应的强度和持续时间的模型研究提出了具体问题。目前，还没有专门设计实地研究来解决这些问题。因此，需要进行明确设计的实地研究，以捕捉获得性免疫的流行病学影响，以阐明这些免疫相互作用。在此过程中，重要的是解决理论建模者和免疫流行病学家之间的讨论，并开发凭经验定义免疫参数的机制模型。在长期实施 MDA 后传播动态可能发生变化的环境下，这一点变得越来越重要。
Mass drug administration (MDA) for control of schistosomiasis is likely to affect transmission dynamics through a combination of passive vaccination and reduction of local transmission intensity. This is indicated in phenomenological models of immunity and the impact of MDA, yet immunity parameters in these models are not validated by empirical data that reflects protective immunity to reinfection. There is significant empirical evidence supporting the role of IgE in acquired protective immunity. This is proposed to be a form of delayed concomitant immunity, driven at least in part by protective IgE responses to the tegument allergen-like (TAL) family of proteins. Specific questions have arisen from modeling studies regarding the strength and duration of the protective immune response. At present, field studies have not been specifically designed to address these questions. There is therefore a need for field studies that are explicitly designed to capture epidemiological effects of acquired immunity to elucidate these immunological interactions. In doing so, it is important to address the discourse between theoretical modelers and immuno-epidemiologists and develop mechanistic models that empirically define immunity parameters. This is of increasing significance in a climate of potential changing transmission dynamics following long-term implementation of MDA.