Lipid-soluble and water-soluble arsenic compounds in blubber of ringed seal (Pusa hispida).
Lipid-soluble and water-soluble arsenic compounds in blubber of ringed seal (Pusa hispida).
复制标题
环斑海豹（Pusa hispida）脂肪中的脂溶性和水溶性砷化合物。
DOI：
10.1016/s0039-9140(03)00369-2
复制
发表时间：
2003
期刊：
影响因子：
6.1
通讯作者：
S. Tanabe
中科院分区：
文献类型：
--
作者：
Kenichiro Ebisuda;T. Kunito;J. Fujihara;R. Kubota;Y. Shibata;S. Tanabe
在我们以前的研究中，在环斑海豹（Pusa hispida）的鲸脂中观察到高浓度的砷。为了更好地了解砷在海洋哺乳动物脂肪中的积累情况，采用高效液相色谱-电感耦合等离子体质谱（HPLC-ICPMS）对环斑海豹脂肪中的砷进行了分析。最主要的水溶性砷的鲸脂是二甲基胂酸（DMA），尽管在其他组织中的优势arsenobetaine。在温和（四乙基氢氧化铵（TEAH）水解）和强（NaOH水解）条件下水解脂溶性部分，然后将等份水解产物进样至HPLC-ICPMS。TEAH不稳定和TEAH稳定/NaOH不稳定的脂溶性级分都含有DMA的前体。这些结果表明，鲸脂可能是环斑海豹中DMA和含DMA前体的集合。
High concentrations of arsenic were observed in the blubber of ringed seals (Pusa hispida) in our previous study. To better understand the arsenic accumulation in blubber of marine mammals, arsenicals in the blubber of ringed seal were characterized using high performance liquid chromatography–inductively coupled plasma mass spectrometry (HPLC–ICPMS). The most predominant water-soluble arsenical in the blubber was dimethylarsinic acid (DMA), in spite of the predominance of arsenobetaine in other tissues. Lipid-soluble fraction was hydrolyzed under mild (tetraethylammonium hydroxide (TEAH) hydrolysis) and strong (NaOH hydrolysis) conditions, and then an aliquot of hydrolysate was injected onto HPLC–ICPMS. Both TEAH-labile and TEAH-stable/NaOH-labile lipid-soluble fractions contained precursors of DMA. These results suggest that the blubber might be the pool of DMA and DMA-containing precursors in ringed seals.
二甲基胂酸诱导大鼠尿路上皮细胞毒性和再生。
DOI：
10.1093/toxsci/59.1.68
发表时间：
2001
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Cohen,SM;Yamamoto,S;Cano,M;Arnold,LL
通讯作者：
Arnold,LL