Characteristic neuropathology of leukomalacia in extremely low birth weight infants
Characteristic neuropathology of leukomalacia in extremely low birth weight infants
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DOI：
10.1016/s0887-8994(97)00041-6
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发表时间：
1997-05-01
影响因子：
3.8
通讯作者：
Takashima, S
中科院分区：
文献类型：
--
作者：
Deguchi, K;Oguchi, K;Takashima, S
本文采用神经病理学和免疫组化方法对85例极低出生体重儿（ELBW）脑室周围白质软化症（PVL）进行了检查，在妊娠23 ~ 27周出生的85例极低出生体重儿（ELBW）脑室周围白质软化症（PVL）中有13例显示PVL从深部到中间白质广泛分布，免疫组化显示胶质纤维酸性蛋白（GFAP）阳性星形胶质细胞在深部白质中增加。在所有PVL病例中，常扩散到中间白质。肿瘤坏死因子- α (tnf - α)阳性细胞在69%的PVL病例的深部至中层白质中发现，并且从妊娠23周开始出现的时间比对照组早。-淀粉样蛋白前体蛋白（beta APP）阳性轴突在PVL周围的深部至中间白质中发现，占85%。在年龄匹配的对照组ELBW婴儿中，从未发现GFAP-、tnf - α -或β app -阳性细胞。因此，在ELBW婴儿中，广泛的轴突损伤和胶质细胞激活与细胞因子的产生发生在特征性PVL病变的进展中。(C) 1997年由爱思唯尔科学公司版权所有。
Extremely low birth weight (ELBW) infants with periventricular leukomalacia (PVL) were examined by neuropathological and immunohistochemical methods, Thirteen ELBW infants of 85 infants with PVL, born at 23 to 27 weeks of gestation, showed a widespread type of distribution of PVL from the deep to intermediate white matter, Immunohistochemistry demonstrated glial fibrillary acidic protein (GFAP)-positive astrocytes to be increased in the deep white matter, often spreading to the intermediate white matter, in all cases of PVL. Tumor necrosis factor-alpha (TNF-alpha)-positive cells were found in the deep to intermediate white matter in 69% of PVL cases and appeared earlier, from 23 weeks of gestation, than in controls. beta-Amyloid precursor protein (beta APP)-positive axons were found around PVL in the deep to intermediate white matter in 85% of the cases. In age-matched control ELBW infants, GFAP-, TNF-alpha-, or beta APP-positive cells were never found, Therefore, in ELBW infants, widespread axonal damage and glial activation with cytokine production occur in the progression of characteristic PVL lesions. (C) 1997 by Elsevier Science Inc. All rights reserved.