Local anaesthetic activity of β-caryophyllene
Local anaesthetic activity of β-caryophyllene
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DOI：
10.1016/s0014-827x(01)01092-8
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发表时间：
2001-05-01
期刊：
影响因子：
--
通讯作者：
Bartolini, A
中科院分区：
文献类型：
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作者：
Ghelardini, C;Galeotti, N;Bartolini, A
本文研究了桃金娘科植物丁香（Syzygium aromaticum）干燥花蕾中丁香油的主要成分β-香紫苏烯的局部麻醉活性。我们将其活性与一种化学相关的化合物-环氧乙烷进行了比较。在兔结膜反射试验中评价了体内麻醉活性，在大鼠膈神经-半膈制备物中评价了体外麻醉活性。β-香紫苏烯（10（-4）-1 μ g/ml），而不是香紫苏烯氧化物，能够以剂量依赖性方式显著降低大鼠膈半横隔膜的电诱发收缩。在兔中，用β-卡连素溶液（10-1000 μ g/ml）进行结膜反射试验处理，可使激发反射所需的刺激物数量呈剂量依赖性增加。总之，这些数据证明了β-香紫苏烯的局部麻醉活性，这似乎严格依赖于其化学结构。(C)2001年，Elsevier SAS科学与医学版。
In this work we studied the local anaesthetic activity of beta-caryophyllene, one of the main components of clove oil obtained from the dried flower-buds of Syzygium aromaticum (Myrtaceae family). We compared its activity to a chemically related compound, caryophyllene oxide. Anaesthetic activity was evaluated in vivo in the rabbit conjunctival reflex test and in vitro in a rat phrenic nerve-hemidiaphragm preparation. beta-Caryophyllene (10(-4)-1 mug/ml), but not caryophyllene oxide, was able to reduce drastically, in a dose-dependent manner, the electrically evoked contractions of the rat phrenic hemidiaphragm. In the rabbit, conjunctival reflex test treatment with a solution of beta-caryophyllene (10-1000 mug/ml) allowed a dose-dependent increase in the number of stimuli necessary to provoke the reflex. As in the in vitro results, caryophyllene oxide was ineffective also in the in vivo test.In conclusion, these data evidence the local anaesthetic activity of beta-caryophyllene, which appears to be strictly dependent on its chemical structure. (C) 2001 Editions scientifiques et medicales Elsevier SAS.