Immunologic effects of hydralazine in hypertensive patients.
Immunologic effects of hydralazine in hypertensive patients.
复制标题
肼屈嗪对高血压患者的免疫学作用。
作者：
Allen Litwin;Louis E. Adams;H. Zimmer;Evelyn V. Hess
Twenty-seven hypertensive patients (23 blacks, 4 whites) treated with hydralazine had frequent serologic evidence of autoimmunity. However, only 1 patient developed a lupus syndrome. Acetylator phenotype influenced the autoimmune response; slow acetylators had a higher incidence and titers of autoantibodies. The lupus patient not only had high titers of autoantibodies but they were predominantly IgG in contrast to the predominant IgM antibodies found in other slow acetylators. Hydralazine treatment did not alter cell-mediated immune responses and hydralazine antibodies were not detected. However, half the patients tested who received hydralazine had positive lymphoproliferative responses to the drug.
