The effect of locus ceruleus lesion on water, sodium and potassium content of the rat cerebral cortex.
The effect of locus ceruleus lesion on water, sodium and potassium content of the rat cerebral cortex.
复制标题
蓝斑病变对大鼠大脑皮层水、钠、钾含量的影响
DOI：
10.1080/01616412.1989.11739869
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发表时间：
1989
影响因子：
1.9
通讯作者：
Harik,SI
中科院分区：
文献类型：
--
作者：
Moufarrij,NA;Harik,SI
蓝斑损伤可降低脑微血管中哇巴因结合位点的密度，推测可能是Na+，K+-ATP酶。为了确定这种减少是否会影响Na+，K+或水穿过血脑屏障的运输，我们研究了单侧蓝斑病变对同侧大脑皮层Na+，K+和水含量的影响。单侧蓝斑损伤可使同侧大脑皮质去甲肾上腺素耗竭，但对稳态条件下组织Na+、K+或水无影响。当血脑屏障的Na+/K+交换泵受到高钾血症的应激时，同侧大脑皮层中的K+含量升高至高于对侧皮层的水平，但差异未达到统计学显著性。蓝斑病变也没有造成显着差异，在大脑皮层的水含量; Na+或K+在低钠血症。结果表明，脑水和离子稳态受到严格控制，可能是由多种机制与生物冗余，因此，即使在脑内皮细胞中的哇巴因结合位点的密度降低50%不会导致脑水，Na+或K+含量的显着改变。
Locus ceruleus lesion decreases the density of ouabain binding sites, and presumably Na+, K+-ATPase, in brain microvessels. To determine if this decrease affects the transport of Na+, K+or water across the blood-brain barrier, we studied the influence of unilateral locus ceruleus lesion on Na+, K+and water content of the ipsilateral cerebral cortex. Unilateral locus ceruleus lesion depleted norepinephrine in the ipsilateral cerebral cortex but had ho effect on tissue Na+, K+or water under steady-state conditions. When the Na+/K+exchange pump of the blood-brain barrier was stressed by hyperkalaemia, K+content in the ipsilateral cerebral cortex rose to higher levels than in the contralateral cortex, but the difference did not reach statistical significance. Locus ceruleus lesion also did not cause significant differences in the cerebral cortical content of water; Na+or K+in hyponatraemia. The results suggest that brain water and ion homeostasis are tightly controlled, probably by multiple mechanisms with biological redundancies, so that even a 50% decrease in the density of ouabain binding sites in brain endothelium does not result in significant alterations in brain water, Na+or K+content.