Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study
Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study
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DOI：
10.1016/j.jhep.2007.09.009
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发表时间：
2008-02-01
影响因子：
25.7
通讯作者：
Heathcote, Jenny E.
中科院分区：
文献类型：
--
作者：
Allard, Johane P.;Aghdassi, Elaheh;Heathcote, Jenny E.
背景/目的：低肝n-6和n-3多不饱和脂肪酸(PUFA)可能导致脂肪变性和脂肪性肝炎，并可能受到饮食和氧化应激的影响。方法：对73例肝酶升高并怀疑为NAFLD的患者进行评估。比较单纯性脂肪变性(SS，n=18)、脂肪性肝炎(NASH，n=38)和微小肝活检(MF，n=17)患者的营养状况、肝脏FA组成和氧化应激情况。结果：NASH患者的体重指数(BMI)、中心性肥胖、体脂、胰岛素抵抗、血脂异常和体力活动减少均高于其他组。它们的肝脏n-3和n-6多不饱和脂肪酸相对较低，n-6和n-3脂肪酸的代谢物与必需脂肪酸前体的比率(二十碳五烯酸+二十二碳六烯酸/亚麻酸和花生四烯酸/亚油酸比率)降低，肝脏过氧化脂质含量较高，抗氧化能力较低，与ME相比，SS和NASH的FA组成没有显著差异。三组患者自我报告的膳食摄入量和红细胞FA组成相似。结论：NASH患者存在更多的代谢异常。这与肝脏中较高的氧化应激和较低的n-3和n-6多不饱和脂肪酸有关，而膳食中的FA组成没有任何差异。(C)2007年欧洲肝脏研究协会。爱思唯尔出版，版权所有。
Background/Aims: Low hepatic n - 6 and n - 3 polyunsaturated fatty acid (PUFA) may contribute to steatosis and steatohepatitis and can be affected by diet and oxidative stress.Methods: Seventy-three patients referred for elevated liver enzymes and suspected NAFLD were assessed. Nutritional assessment, hepatic FA composition and oxidative stress were compared between these groups: simple steatosis (SS, n = 18), steatohepatitis (NASH, n = 38) and minimal findings on liver biopsy (MF, n = 17).Results: Patients with NASH had higher: BMI, central obesity, body fat, insulin resistance, dyslipidemia and lower physical activity compared to the other groups. They also had relatively lower hepatic n - 3 and n - 6 PUFA, a decrease in the ratio of metabolites to essential FA precursors for both n - 6 and it - 3 FA (eicosapentaenoic + docosahexaenoic/ linolenic and arachidonic/linoleic acid ratios) and higher liver lipid peroxides with lower antioxidant power, when compared to ME Overall, there was no significant difference between SS and NASH in FA composition. Self-reported dietary intake and red blood cell FA composition were similar among the three groups.Conclusions: NASH patients have more metabolic abnormalities. This is associated with higher oxidative stress and lower n - 3 and n - 6 PUFA in the liver in the absence of any differences in dietary FA composition. (c) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.