Clinical and diagnostic features of in situ melanoma and superficial spreading melanoma: a hospital based study
Clinical and diagnostic features of in situ melanoma and superficial spreading melanoma: a hospital based study
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DOI：
10.1111/j.1468-3083.2011.04015.x
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发表时间：
2012-02-01
影响因子：
9.2
通讯作者：
Girolomoni, G.
中科院分区：
文献类型：
--
作者：
Rosina, P.;Tessari, G.;Girolomoni, G.
研究背景原位黑色素瘤（in-situ melanoma，in-situ melanoma）的发病率不断上升，但对其临床和诊断特点的研究却很少目的探讨原位黑色素瘤（in-situ melanoma，in-situ melanoma，in-situ melanoma）与浅表扩散性黑色素瘤（superficial spreading melanoma，SSM）的临床和诊断特点。入组了90例连续原位黑色素瘤患者和90例年龄和性别匹配的SSM患者。主要结果指标是引起原位黑色素瘤怀疑的临床体征的差异，结果原位黑色素瘤的中位直径小于SSM，而SSM的中位直径小于SSM，SSM的中位直径小于SSM，SSM的中位直径小于SSM 47.8%的原位黑色素瘤直径小于6 mm，而25.6%的SSM直径小于6 mm（P < 0.002）。原位黑色素瘤主要由皮肤科医生检测（比值比2.95，P = 0.018），并且在超过10个黑色素细胞痣的患者中检测（比值比3.12，P = 0.008）。与皮肤科咨询的早期要求独立相关的临床因素是年龄大于45岁（比值比3.47，P = 0.002）和病变的位置在一个难以观察的皮肤网站（比值比4.20，P = 0.001），但不Breslow的thicken.Conclusions我们的研究结果表明，原位黑色素瘤和SSM共享相似的临床特征和早期预警信号。然而，原位黑色素瘤的大小比SSM小。这可能对早期诊断和预防策略具有重要意义。
Background Despite the incidence of in situ melanoma is continuously rising; few studies have investigated its clinical and diagnostic features.Objective To investigate clinical and diagnostic features of in situ melanoma compared to superficial spreading melanoma (SSM).Methods This is a hospital based, case- control study. Ninety consecutive patients with an in situ melanoma and 90 age and gender matched patients with SSM were enrolled. Main outcome measures were differences in clinical signs that aroused suspicion of in situ melanoma, detection modalities (self- detection vs. incidental detection by a physician), factors conditioning time between first noticing the suspect lesions and the physician visit.Results Median diameter of in situ melanoma was smaller than SSM (7.5 vs. 9.0 mm, P < 0.024), and 47.8% of in situ melanomas were smaller than 6 mm, in contrast to 25.6% of SSM (P < 0.002). In situ melanoma was mainly detected by a dermatologist (Odds Ratio 2.95 P = 0.018), and in patients with more than 10 melanocytic naevi (Odds Ratio 3.12, P = 0.008). Clinical factors independently associated to early request of dermatological consultation were age older than 45 years (Odds ratio 3.47, P = 0.002) and location of lesion in a difficult observation skin site (Odds ratio 4.20, P = 0.001), but not Breslow's thickness.Conclusions Our findings show that in situ melanoma and SSM share similar clinical characteristics and early warning signs. However, in situ melanoma is smaller in size than SSM. This may have important implications for early diagnosis and prevention strategies.