Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
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甲硝唑加阿莫西林治疗放线杆菌相关牙周炎的微生物学和临床结果。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
J. Graaff
中科院分区：
文献类型：
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作者：
A. J. Winkelhoff;C. J. Tijhof;J. Graaff
我们报告了机械清创联合甲硝唑加阿莫西林治疗对 118 名放线杆菌伴放线菌相关牙周炎患者的微生物学和临床效果。患者被分为 3 组：28 人患有局部牙周炎； 50 名患有广泛性牙周炎，40 名患有难治性牙周炎。经过初始治疗和甲硝唑加阿莫西林治疗后，118 名患者中的 114 名 (96.6%) 没有检测到放线放线菌伴生菌。几乎所有患者都实现了口袋探诊深度的显着减少和临床附着力的增强。治疗后，四名患者的伴放线放线菌仍呈阳性。在这些患者的 4 株菌株中，有 2 株观察到甲硝唑耐药（MIC 大于 25 微克/毫升）。伴放线菌或牙龈卟啉单胞菌仍呈阳性的患者在治疗后表现出明显较高的出血倾向。结论是机械牙周治疗联合甲硝唑加阿莫西林治疗可有效抑制严重牙周炎患者龈下伴放线放线菌。
We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis. Patients were categorized into 3 groups: 28 had localized periodontitis; 50 had generalized periodontitis, and 40 had refractory periodontitis. After initial treatment and metronidazole plus amoxicillin therapy 114 of 118 (96.6%) patients had no detectable A. actinomycetemcomitans. Significant reduction in pocket probing depth and gain of clinical attachment were achieved in almost all patients. Four patients were still positive for A. actinomycetemcomitans after therapy. Metronidazole resistance (MIC greater than 25 micrograms/ml) was observed in 2 of 4 strains from these patients. Patients still positive for A. actinomycetemcomitans or Porphyromonas gingivalis showed a significant higher bleeding tendency after therapy. It was concluded that mechanical periodontal treatment in combination with the metronidazole plus amoxicillin therapy is effective for subgingival suppression of A. actinomycetemcomitans in patients with severe periodontitis.
手术加强力霉素对幼年牙周炎的微生物学和临床效果。
影响因子：
4.3
作者：
Mandell,RL;Socransky,SS
通讯作者：
Socransky,SS
影响因子：
6.7
作者：
DZINK, JL;SOCRANSKY, SS;HAFFAJEE, AD
通讯作者：
HAFFAJEE, AD