The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?
The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?
复制标题
富含半胱氨酸的酸性分泌蛋白 (SPARC) 在心脏修复和纤维化中的作用：巨噬细胞表达 SPARC 是否会影响结果？
DOI：
10.1016/j.yjmcc.2015.11.014
复制
发表时间：
2016-04-01
影响因子：
5
通讯作者：
Bradshaw, Amy D.
中科院分区：
文献类型：
--
作者：
Bradshaw, Amy D.
富含半胱氨酸的酸性分泌蛋白(SPARC)是一种基质细胞、胶原结合蛋白。基质细胞蛋白被描述为与细胞外基质相关的蛋白质，在基质中不起经典的结构作用，例如那些归因于层粘连蛋白和胶原蛋白的蛋白质。基质细胞蛋白家族调节细胞与细胞外基质的相互作用，并在组织重塑过程中活跃表达。SPARC在培养细胞中的功能活动包括调节细胞黏附、细胞骨架重排、增殖和基质组装。SPARC基因缺失小鼠的主要表型特征是纤维胶原和纤维形态的数量不足。引人注目的是，SPARC基因缺失的小鼠在许多不同的组织环境中表现出钝化的纤维化反应。单核/巨噬细胞作为组织纤维化的重要组成部分，其作用日益受到重视。骨髓炎性细胞SPARC的表达提出了一个有趣的命题，即由白细胞渗入产生的SPARC可能参与了心脏炎症和组织纤维化的过程。这篇综述将总结定义SPARC在心肌修复和纤维化中的功能的研究结果，以及其他非心脏组织的研究结果，这些研究揭示了单核/巨噬细胞表达SPARC在心脏病发病中的可能后果。(C)爱思唯尔有限公司出版的2015年。
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular, collagen-binding protein. Matricellular proteins are described as extracellular matrix-associated proteins that do not serve classical structural roles in the matrix such as those ascribed to laminins and collagens. The family of matricellular proteins modulates cell:extracellular matrix interactions and is actively expressed during tissue remodeling. Functional activities attributed to SPARC in cultured cells include regulation of cell adhesion, cytoskeletal rearrangement, proliferation, and matrix assembly. The primary phenotype characteristic of SPARC-null mice is a deficit in amounts of fibrillar collagen and fibril morphology. Strikingly, SPARC-null mice demonstrate a blunted fibrotic response in a number of different tissue settings. The role of monocyte/macrophages as an important component of tissue fibrosis is becoming increasingly appreciated. Expression of SPARC by bone marrow derived inflammatory cells raises the interesting proposition that SPARC produced by infiltrating leukocytes might contribute to the course of inflammation and tissue fibrosis in the heart. This review will summarize results from studies defining the function of SPARC in myocardial repair and fibrosis and results from other non-cardiac tissues that shed light onto possible consequences of SPARC expression by monocyte/macrophages in the setting of heart disease. (C) 2015 Published by Elsevier Ltd.