Stress regulation of kisspeptin in the modulation of reproductive function.
Stress regulation of kisspeptin in the modulation of reproductive function.
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DOI：
10.1007/978-1-4614-6199-9_20
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发表时间：
2013
影响因子：
--
通讯作者：
P. Grachev;Xiao Feng Li;K. O'Byrne
中科院分区：
文献类型：
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作者：
P. Grachev;Xiao Feng Li;K. O'Byrne
压力刺激在现代社会中比比皆是，并通过改变生殖发育，行为和生理来塑造进化。kisspeptin作为下丘脑调节回路的一个重要组成部分，参与生殖稳态的最近鉴定引发了大量的研究兴趣，随后牵连kisspeptin信号在中继的代谢，环境和生理线索下丘脑-垂体-性腺轴。然而，尽管人们广泛认识到，暴露于压力深刻影响生殖功能，kisspeptin的复杂机制的压力调节生殖的作用仍然知之甚少。我们和其他人最近已经证明，各种实验应激范式下调生殖脑内kisspeptin配体和受体的表达。巧合的是，这些压力也抑制促性腺激素分泌和延迟青春期的发病过程，依赖于kisspeptin信号。然而，一个温和的文献是不一致的，完全抑制压力对生殖轴的影响，并建议复杂的神经相互作用和信号传导机制翻译成生殖干扰的压力反应。本章的目的是审查的证据，一个新的作用，kisspeptin信号调节生殖功能的压力和扩大理解这一及时的现象。
Stressful stimuli abound in modern society and have shaped evolution through altering reproductive development, behavior, and physiology. The recent identification of kisspeptin as an important component of the hypothalamic regulatory circuits involved in reproductive homeostasis sparked a great deal of research interest that subsequently implicated kisspeptin signaling in the relay of metabolic, environmental, and physiological cues to the hypothalamo–pituitary–gonadal axis. However, although it is widely recognized that exposure to stress profoundly impacts on reproductive function, the roles of kisspeptin within the complex mechanisms underlying stress regulation of reproduction remain poorly understood. We and others have recently demonstrated that a variety of experimental stress paradigms downregulate the expression of kisspeptin ligand and receptor within the reproductive brain. Coincidently, these stressors also inhibit gonadotropin secretion and delay pubertal onset—processes that rely on kisspeptin signaling. However, a modest literature is inconsistent with an exclusively suppressive influence of stress on the reproductive axis and suggests that complicated neural interactions and signaling mechanisms translate the stress response into reproductive perturbations. The purpose of this chapter is to review the evidence for a novel role of kisspeptin signaling in the modulation of reproductive function by stress and to broaden the understanding of this timely phenomenon.