Serum sIL-2r, IL-6, IL-10 and TNF-α level in familial Mediterranean fever patients
Serum sIL-2r, IL-6, IL-10 and TNF-α level in familial Mediterranean fever patients
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DOI：
10.1007/s10067-002-0682-1
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发表时间：
2003-05-01
影响因子：
3.4
通讯作者：
Inal, A
中科院分区：
文献类型：
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作者：
Baykal, Y;Saglam, K;Inal, A
在这项研究中，我们调查了家族性地中海热 (FMF) 患者的细胞因子水平。包括 20 名患者和 20 名健康对照。 10名患者出现FMF急性发作，其余10名患者处于沉默期。 FMF急性加重期患者的可溶性白细胞介素2受体（sIL-2r）、白细胞介素6（IL-6）、肿瘤坏死因子-α、红细胞沉降率（ESR）、C反应蛋白（CRP）和纤维蛋白原水平高于静默期（P < 0.001）和对照组（P < 0.001）。在FMF急性发作的患者中，白细胞介素10（IL-10）水平与其他患者或对照组没有显着差异（P > 0.05）。在FMF患者中，IL-6、TNF-α、sIL-2r、ESR、CRP和纤维蛋白原水平随着急性期反应而升高，尤其是在发作期。另一方面，抗炎细胞因子 IL-10 水平的增加幅度不如炎性细胞因子。细胞因子之间的平衡可能有助于我们了解 FMF 的病理生理学并开发治疗方法。我们的结论是，急性期反应物和细胞因子的水平可用于急性加重的诊断、随访和治疗。然而，目前细胞因子测量分析的成本似乎是不利的。
In this study we investigated cytokine levels in patients with familial Mediterranean fever (FMF). Twenty patients and 20 healthy controls were included. Ten patients had acute attacks of FMF, whereas the other 10 were in the silent period. Patients with the acute exacerbation of FMF had higher soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), tumour necrosis factor-alpha, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and fibrinogen levels than those in the silent period (P < 0.001) and controls (P < 0.001). In patients with acute attacks of FMF, interleukin-10 (IL-10) levels were not significantly different from those in the other patients or the controls (P > 0.05). In FMF patients IL-6, TNF-alpha, sIL-2r, ESR, CRP and fibrinogen levels increased with the acute-phase reaction, especially in the attack period. On the other hand, anti-inflammatory cytokine IL-10 levels did not increase as much as did the inflammatory cytokines. The balance between the cytokines may help us to understand the pathophysiology of FMF and to develop therapies. We conclude that the levels of the acute-phase reactants and the cytokines could be useful for diagnosis of acute exacerbations, follow-up and treatment. However, the cost of cytokine measurement analyses seems disadvantageous at present.