1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice
1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice
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1, 8-桉树脑可预防小鼠流感病毒引起的肺炎
DOI：
10.1007/s10753-016-0394-3
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发表时间：
2016-08-01
期刊：
影响因子：
5.1
通讯作者：
Xu, Peiping
中科院分区：
文献类型：
--
作者：
Li, Yun;Lai, Yanni;Xu, Peiping
1，8-桉叶醇是主要来自桉树精油的主要单萜，并且已显示出具有抗炎、抗病毒和抑制核因子（NF）-kB的作用。在本研究中，我们评估了1，8-桉叶油素对感染A型流感病毒的小鼠的作用。我们发现，1，8-桉叶油素可保护小鼠免受流感病毒感染。此外，1，8-桉叶油醇有效降低鼻灌洗液中IL-4、IL-5、IL-10和MCP-1的水平以及感染流感病毒的小鼠肺组织中IL-1 β、IL-6、TNF-α和IFN-γ的水平。结果还显示，1，8-桉叶油醇降低肺组织NF-κ B p65、细胞间粘附分子（ICAM）-1和血管细胞粘附分子（VCAM）-1的表达。因此，1，8-桉叶油醇似乎能够通过减弱肺部炎症反应来增强对小鼠中IFV感染的保护。
1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1 beta, IL-6, TNF-alpha, and IFN-gamma in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.