Enzymatic synthesis of n-octyl (+)-2-methylbutanoate ester from racemic (±)-2-methylbutanoic acid by immobilized lipase:: optimization by statistical analysisle
Enzymatic synthesis of n-octyl (+)-2-methylbutanoate ester from racemic (±)-2-methylbutanoic acid by immobilized lipase:: optimization by statistical analysisle
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DOI：
10.1016/s0141-0229(01)00462-8
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发表时间：
2002-01-08
影响因子：
3.4
通讯作者：
Aracil, J
中科院分区：
文献类型：
--
作者：
García, R;Renedo, A;Aracil, J
在间歇反应器中，以正辛醇和固定化假丝酵母脂肪酶为生物催化剂，以外消旋(+/-)-甲基丁二酸为原料，采用不对称酯化反应直接合成(+)-2-甲基丁酸正辛酯。在该精细化学品的合成中，采用了析因实验设计和中心合成设计。选择的变量为温度和催化剂初始浓度。用响应面模型来表示酯产率和剩余酸的对映体过量。(C)2002 Elsevier Science Inc.保留所有权利。
An enantioselective esterification process was developed for the direct synthesis of n-octyl (+)-2-methylbutanoate ester from racemic (+/-)-methylbutanoaic acid by using n-octanol and Candida antarctica immobilized lipase as the biocatalyst in a batch reactor. A Factorial Design of Experiments and a Central Composite Design have been used in the synthesis of this fine chemical. The variables chosen were temperature and initial catalyst concentration. Response surface models were applied to represent the yield of ester and the enantiomeric excess of the remaining acid. (C) 2002 Elsevier Science Inc. All rights reserved.