Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.
Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.
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DOI：
10.1146/annurev-immunol-093019-110159
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发表时间：
2021-04-26
影响因子：
29.7
通讯作者：
Quintana FJ
中科院分区：
文献类型：
--
作者：
Prinz M;Masuda T;Wheeler MA;Quintana FJ
中枢神经系统（CNS）的免疫系统主要由先天免疫细胞组成。这些是在实质中发现的高度特化的巨噬细胞，称为小胶质细胞，或在CNS界面处发现的高度特化的巨噬细胞，例如软脑膜、血管周围和脉络丛巨噬细胞。虽然它们最初被认为是吞噬细胞，但它们的功能远远超出了在发育和疾病期间简单清除细胞碎片的范围。研究人员发现，大脑固有免疫细胞具有可塑性，寿命长，并且拥有大量多种病理学风险基因。因此，它们现在被认为是调节CNS疾病的最合适的靶标。此外，最近的单细胞技术增强了我们对它们的起源，命运，相互作用组和健康和扰动期间的功能细胞状态的分子理解。在这里，我们回顾了我们对CNS中髓样细胞生物学的理解和挑战的现状以及相关疾病的治疗选择。
The immune system of the central nervous system (CNS) consists primarily of innate immune cells. These are highly specialized macrophages found either in the parenchyma, called microglia, or at the CNS interfaces, such as leptomeningeal, perivascular, and choroid plexus macrophages. While they were primarily thought of as phagocytes, their function extends well beyond simple removal of cell debris during development and diseases. Brain-resident innate immune cells were found to be plastic, long-lived, and host to an outstanding number of risk genes for multiple pathologies. As a result, they are now considered the most suitable targets for modulating CNS diseases. Additionally, recent single-cell technologies enhanced our molecular understanding of their origins, fates, interactomes, and functional cell states during health and perturbation. Here, we review the current state of our understanding and challenges of the myeloid cell biology in the CNS and treatment options for related diseases.
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影响因子：
16.2
作者：
Abud EM;Ramirez RN;Martinez ES;Healy LM;Nguyen CHH;Newman SA;Yeromin AV;Scarfone VM;Marsh SE;Fimbres C;Caraway CA;Fote GM;Madany AM;Agrawal A;Kayed R;Gylys KH;Cahalan MD;Cummings BJ;Antel JP;Mortazavi A;Carson MJ;Poon WW;Blurton-Jones M
通讯作者：
Blurton-Jones M
影响因子：
16.2
作者：
Bennett FC;Bennett ML;Yaqoob F;Mulinyawe SB;Grant GA;Hayden Gephart M;Plowey ED;Barres BA
通讯作者：
Barres BA
影响因子：
56.9
作者：
Cartier, Nathalie;Hacein-Bey-Abina, Salima;Aubourg, Patrick
通讯作者：
Aubourg, Patrick
影响因子：
30.5
作者：
Buttgereit, Anne;Lelios, Iva;Greter, Melanie
通讯作者：
Greter, Melanie
影响因子：
25
作者：
Ajami, Bahareh;Bennett, Jami L.;Rossi, Fabio M. V.
通讯作者：
Rossi, Fabio M. V.