Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
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DOI：
10.1086/429327
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发表时间：
2005-05-01
影响因子：
11.8
通讯作者：
Soriano, V
中科院分区：
文献类型：
--
作者：
Rodriguez-Novoa, S;Barreiro, P;Soriano, V
我们检测了100例接受依法韦仑（EFV）治疗的人类免疫缺陷病毒阳性受试者中编码细胞色素P450基因的516 G>T多态性。在40%的多态性纯合基因型受试者和19%的杂合基因型受试者中发现血浆EFV浓度升高。相反，20%的野生型基因型受试者的EFV浓度低于治疗浓度。CYP 2B 6 -516基因分型可能有助于识别血浆EFV浓度超出治疗范围的受试者。
We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.