Origin DNA-binding proteins
Origin DNA-binding proteins
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DOI：
10.1016/s0959-440x(98)80009-2
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发表时间：
1998-02-01
影响因子：
6.8
通讯作者：
Frappier, L
中科院分区：
文献类型：
--
作者：
Edwards, AM;Bochkarev, A;Frappier, L
DNA复制的第一步涉及到起源结合蛋白对起源DNA序列的识别。最近，三种不同来源的DNA结合蛋白的三维结构已经被解决。这些蛋白质形成了不同于其他DNA结合蛋白的结构类别。来源结合蛋白之一，EB病毒核抗原1，很可能有两种模式的DNA结合；这些模式的顺序使用可能是重要的DNA复制的启动。
The first step in DNA replication involves the recognition of origin DNA sequences by origin-binding proteins. The three-dimensional structures of three different origin DNA-binding proteins have recently been solved. These proteins form a structural class distinct from other DNA-binding proteins. One of the origin-binding proteins, Epstein-Barr virus nuclear antigen 1, most likely has two modes of DNA binding; the sequential use of these modes may be important for the initiation of DNA replication.