Adiponectin gene variation-4522C/T is associated with type 2 diabetic obesity and insulin resistance in Chinese
Adiponectin gene variation-4522C/T is associated with type 2 diabetic obesity and insulin resistance in Chinese
复制标题
脂联素基因变异-4522C/T与中国人2型糖尿病肥胖和胰岛素抵抗相关。
DOI：
10.1016/s1673-8527(07)60099-x
复制
发表时间：
2007-10-01
影响因子：
5.9
通讯作者：
Li, Xuefei
中科院分区：
文献类型：
--
作者：
Liu, Hekun;Chen, Suyun;Li, Xuefei
作者探讨了脂联素基因-4522C/T变异与冠心病（CHD）和2型糖尿病（T2DM）的可能关联。采用PCR-RFLP方法对304例冠心病患者、389例T2DM患者和405例年龄和性别匹配的健康对照进行SNP -4522C/T基因分型。冠心病患者与对照组、T2DM患者与对照组的基因型和等位基因频率均无显著差异。然而，在亚组分析中，发现T/T基因型和T等位基因与2型糖尿病合并肥胖（BMI >= 25 kg/m(2)）存在相关性（P = 0.014和P = 0.034）。T/T基因型T2DM患者胰岛素抵抗的稳态模型评估（HOMA-IR）显著高于携带C等位基因的T2DM患者（P = 0.0069）。作者的研究结果首次证实了脂联素基因SNP -4522与T2DM患者合并肥胖和较高胰岛素抵抗指数相关。这表明这种变异可能与2型糖尿病肥胖和胰岛素抵抗的易感性增加有关。但-4522C/T多态性与冠心病易感性无关。
The authors investigated the possible association of -4522C/T variation of adiponectin gene with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Genotyping of SNP -4522C/T in 304 patients with CHD, 389 patients with T2DM, and 405 age and sex-matched healthy control subjects was carried out by means of PCR-RFLP approach. No significant difference in the genotype or allele frequencies was found, either between patients with CHD and control subjects, or between patients with T2DM and control subjects. However, in the subgroup analysis, an association of the T/T genotype and T allele with type 2 diabetes combined with obesity (BMI >= 25 kg/m(2)) was found (P = 0.014 and P = 0.034, respectively). Also the homeostasis model assessment of insulin resistance (HOMA-IR) in T2DM patients with T/T genotype was significantly higher than that in T2DM patients carrying C allele (P = 0.0069). The authors' findings for the first time demonstrated that SNP -4522 in the adiponectin gene was associated with T2DM that combined with obesity and higher insulin resistance index in patients with T2DM. This indicated that the variation might associate with an increased susceptibility to type 2 diabetic obesity and insulin resistance. But -4522C/T polymorphism did not contribute to the susceptibility of CHD.