Transplantation Antigens in the Central Nervous System
Transplantation Antigens in the Central Nervous System
复制标题
中枢神经系统中的移植抗原
DOI：
10.1038/225647a0
复制
发表时间：
1970
期刊：
影响因子：
64.8
通讯作者：
A. G. Gervais
中科院分区：
文献类型：
--
作者：
A. G. Gervais
对小鼠脑中存在组织相容性抗原的研究给出了明显矛盾的结果。血凝素1、2和细胞毒素3抑制研究表明，与淋巴组织相比，大脑吸收H-2抗体的能力非常小。然而，脑组织诱导移植免疫4，并且通过免疫荧光5在大脑皮层的神经元中检测到组织相容性抗原。特异性荧光对神经元的选择性定位可以解释这些相互矛盾的结果，因为染色细胞的数量只占整个脑组织的一小部分。这将通过定量抑制研究中非常低的吸收能力来反映。
INVESTIGATIONS into the presence of histocompatibility antigens in mouse brain have given apparently conflicting results. Haemagglutinin1,2 and cytotoxin3 inhibition studies have revealed that the brain has an extremely small capacity for absorbing H-2 antibodies, compared with lymphoid tissues. Brain tissue, however, induces transplantation immunity4 and histocompatibility antigens are detected in neurones of the cerebral cortex by immuno-fluorescence5. The selective localization of the specific fluorescence to the neurones can explain these conflicting results, for the number of stained cells represents only a small proportion of the total brain tissue. This will be reflected by a very low absorptive capacity in quantitative inhibition studies.