Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa
Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa
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DOI：
10.1016/s0952-3278(98)90079-5
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发表时间：
1998-11-01
影响因子：
3
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Sawaoka, H;Kawano, S;Hori, M
最近的研究表明，有丝分裂原诱导的环氧合酶-2 （COX-2）在胃肠道肿瘤中表达。我们利用免疫组织化学方法研究了幽门螺杆菌感染对胃COX-2表达的影响，幽门螺杆菌是人类胃的一类致癌物。没有宏观病变的人类受试者，通过内窥镜筛查确定，活组织检查幽门螺杆菌感染。对活检标本进行免疫组织化学检测COX-2表达。COX-2在所有幽门螺杆菌感染者的胃上皮和上皮下炎症细胞中表达。幽门螺杆菌阴性组胃黏膜未见COX-2表达。COX-2在胃肠道癌、胃肠道癌细胞期和致癌性治疗后的肠道中均有表达。本研究表明幽门螺杆菌感染导致胃黏膜表达COX-2，表明该酶参与了人类幽门螺杆菌相关的胃病理。
Recent studies indicate that expression of mitogen-inducible cyclooxygenase-2 (COX-2) occurs in gastrointestinal tumors. We investigated the effects of Helicobacter pylori (H. pylori) infection, a class I carcinogen for the human stomach, on gastric COX-2 expression using immunohistochemistry. Human subjects without macroscopic lesions, as determined by endoscopic screening, were biopsied for H. pylori infection. The biopsy samples were immunohistochemically examined for COX-2 expression. COX-2 was expressed in gastric epithelia and subepithelial inflammatory cells in all H. pylori-infected subjects. There was no expression of COX-2 in the gastric mucosa of H. pylori-negative subjects. COX-2 expression has been reported in gastrointestinal carcinomas, gastrointestinal cancer cell-tines, and in the gut after carcinogenic treatment. The present study demonstrates that H. pylori infection leads to gastric mucosal expression of COX-2, indicating that the enzyme is involved in H. pylori-related gastric pathology in humans.