Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells
Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells
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培养的人脂肪间充质干细胞的单细胞 RNA-seq
DOI：
10.1038/sdata.2019.31
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发表时间：
2019-02-26
期刊：
影响因子：
9.8
通讯作者：
Zhou, Zhou
中科院分区：
文献类型：
--
作者：
Liu, Xuanyu;Xiang, Qinqin;Zhou, Zhou
脂肪来源的间充质干细胞(ADSCs)在再生医学中显示出良好的临床应用前景。我们对来自三个捐赠者的24,358个培养的人ADSCs进行了大规模的单细胞转录测序。我们提供了一个高质量的数据集，这将是一个有价值的资源，用于解剖培养的ADSC的群体内异质性，以及在单细胞分辨率下询问任何感兴趣的谱系的谱系启动模式。
Adipose-derived mesenchymal stem cells (ADSCs) show considerable promise for clinical applications in regenerative medicine. We performed a large-scale single-cell transcriptomic sequencing of 24,358 cultured human ADSCs from three donors. We provide a high-quality dataset, which would be a valuable resource for dissecting the intrapopulation heterogeneity of cultured ADSCs as well as interrogating lineage priming patterns for any interested lineages at single-cell resolution.