Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography.
Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography.
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DOI：
10.1371/journal.pone.0269777
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
高血压患者的血流动力学特征是否存在性别差异尚不清楚，但可以指导个性化治疗。我们使用阻抗心动图描述了中国成人高血压的临床和血流动力学特征。我们纳入了 45,082 名高血压患者（定义为收缩压≥130 mmHg 或舒张压≥80 mmHg），其中 35.2% 是女性。总体而言，女性的平均收缩压高于男性（139.0 [±15.7] mmHg vs 136.8 [±13.8] mmHg，P<0.001），但平均舒张压较低（82.6 [±9.0] mmHg vs 85.6 [±8.9] mmHg，P<0.001）。调整年龄、地区和体重指数后，50岁以下的女性比同龄男性具有较低的全身血管阻力指数（β系数[β] -31.7；95% CI：-51.2，-12.2）和较高的心脏指数（β 0.07；95% CI：0.04，0.09），而≥50岁的女性具有较高的全身血管阻力指数（β）。 120.4；95% CI：102.4，138.5），但心脏指数较低（β -0.15；95% CI：-0.16，-0.13）。尽管 SVRI 差异幅度较低且不显着，但结果与倾向评分匹配敏感性分析一致。然而，这些变量的分布图中，女性和男性之间存在大量重叠，重叠面积从 78% 到 88% 不等。我们的研究结果表明，高血压表型存在性别差异，但仅凭性别不足以推断个体的概况。
Whether there are sex differences in hemodynamic profiles among people with elevated blood pressure is not well understood and could guide personalization of treatment. We described the clinical and hemodynamic characteristics of adults with elevated blood pressure in China using impedance cardiography. We included 45,082 individuals with elevated blood pressure (defined as systolic blood pressure of ≥130 mmHg or a diastolic blood pressure of ≥80 mmHg), of which 35.2% were women. Overall, women had a higher mean systolic blood pressure than men (139.0 [±15.7] mmHg vs 136.8 [±13.8] mmHg, P<0.001), but a lower mean diastolic blood pressure (82.6 [±9.0] mmHg vs 85.6 [±8.9] mmHg, P<0.001). After adjusting for age, region, and body mass index, women <50 years old had lower systemic vascular resistance index (beta-coefficient [β] -31.7; 95% CI: -51.2, -12.2) and higher cardiac index (β 0.07; 95% CI: 0.04, 0.09) than men of their same age group, whereas among those ≥50 years old women had higher systemic vascular resistance index (β 120.4; 95% CI: 102.4, 138.5) but lower cardiac index (β -0.15; 95% CI: -0.16, -0.13). Results were consistent with a propensity score matching sensitivity analysis, although the magnitude of the SVRI difference was lower and non-significant. However, there was substantial overlap between women and men in the distribution plots of these variables, with overlapping areas ranging from 78% to 88%. Our findings indicate that there are sex differences in hypertension phenotype, but that sex alone is insufficient to infer an individual’s profile.
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DOI：
10.1161/hypertensionaha.112.201780
发表时间：
2012-12
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cheng S;Xanthakis V;Sullivan LM;Vasan RS
通讯作者：
Vasan RS
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
5.5
作者：
Hart, Emma C.;Charkoudian, Nisha;Joyner, Michael J.
通讯作者：
Joyner, Michael J.
影响因子：
2.4
作者：
Gidwani, Umesh K.;Mohanty, Bibhu;Chatterjee, Kanu
通讯作者：
Chatterjee, Kanu
影响因子：
4.8
作者：
JULIUS, S
通讯作者：
JULIUS, S