Remodeled salt appetite in rat offspring by perinatal exposure to nicotine
Remodeled salt appetite in rat offspring by perinatal exposure to nicotine
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DOI：
10.1016/j.appet.2008.12.013
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发表时间：
2009-04-01
期刊：
影响因子：
5.4
通讯作者：
Xu, Zhice
中科院分区：
文献类型：
--
作者：
Hui, Pengpeng;Rui, Can;Xu, Zhice
为了确定围产期暴露于尼古丁对后代与肾素-血管紧张素系统相关的水摄入量和盐食欲的影响，在围产期[妊娠期（G）或妊娠加哺乳期（G + L）]对母体大鼠皮下注射尼古丁。出生后4个月，1.8%的氯化钠和水的摄入量进行了测量后，24小时的水剥夺在成年后代，并在大脑中的血管紧张素受体进行了测定。在妊娠期或妊娠期加哺乳期暴露于尼古丁后，血液Na+和K+浓度没有变化。对于围产期暴露于尼古丁的后代，24 h禁水显著增加了其盐食欲（在前2 h和24 h测试期间）。在有尼古丁暴露史的子代前脑中，血管紧张素AT（1）和AT（2）亚型的表达减少。结果表明，在围产期使用尼古丁并不改变自发性盐食欲，而刺激性盐摄入量可受到胎儿期尼古丁暴露的影响，围产期尼古丁改变的行为（水和盐摄入）与子代前脑AT（1）和AT（2）受体表达的重塑有关。(C)2009爱思唯尔有限公司保留所有权利。
To determine the effect of perinatal exposure to nicotine on water intake and salt appetite related to renin-angiotensin system in the offspring, maternal rats during perinatal period [gestation (G) or gestation plus lactation (G + L] were subcutaneously administrated with nicotine. Four months after birth, intake of 1.8% NaCl and water was measured following 24 h water deprivation in the adult offspring,and angiotensin receptors in the brain were determined. There was no change of blood Na+ and K+ concentrations following exposure to nicotine either during pregnancy or pregnancy plus lactation. To the offspring following perinatal exposure to nicotine, their salt appetite was significantly increased (during the first 2 h and 24 h testing periods) by 24 h water deprivation. In the forebrain of the offspring with history of perinatal exposure to nicotine, expression of angiotensin AT(1) and AT(2) subtype was reduced. The results showed that spontaneous salt appetite was not changed by using nicotine during perinatal periods, while stimulated salt intake could be affected by exposure to nicotine in fetal origins, and the changed behavior (water and salt intake) by perinatal nicotine was associated with the remodeled expression of AT(1) and AT(2) receptors in the forebrain of the offspring. (C) 2009 Elsevier Ltd. All rights reserved.