Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle
Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle
复制标题
DOI：
10.1037//0735-7044.114.6.1019
复制
发表时间：
2000-12-01
影响因子：
1.9
通讯作者：
Davis, M
中科院分区：
文献类型：
--
作者：
Walker, DL;Davis, M
训练前杏仁核内注入NMDA受体拮抗剂D，L-AP 5，在训练后24+小时测试的大鼠中阻断恐惧增强的惊吓。这可能反映了收购或保留的失败。为了评估这些替代方案，在恐惧条件反射期间（30次光电击配对[0.6 mA电击]）以及恐惧条件反射后1-30分钟和48小时测试大鼠的恐惧增强惊吓。杏仁核病变废除恐惧增强惊吓在所有列车测试的时间间隔。杏仁核内AP 5输注（25 nmol/侧）在长期试验中消除了恐惧增强的惊吓，并在较短的训练试验间隔中产生了部分效果。当短期测试期间的恐惧增强惊吓水平降低到48小时测试的水平时（即，通过用较低的0.3mA足电击训练大鼠），AP 5在每个时间点消除了恐惧增强的惊吓。因此，杏仁核NMDA受体似乎参与了恐惧记忆的最初获得。
Pretraining intra-amygdala infusions of the NMDA receptor antagonist, D,L-AP5, block fear-potentiated startle in rats tested 24+ hr after training. This may reflect a failure of either acquisition or retention. To evaluate these alternatives, rats were tested for fear-potentiated startle during fear conditioning (30 light-shock pairings [0.6 mA shock]), as well as 1-30 min and 48 hr after fear conditioning. Amygdala lesions abolished fear-potentiated startle at all train-test intervals. Intra-amygdala AP5 infusions (25 nmol/side) abolished fear-potentiated startle during the long-term test and had partial effects at shorter train-test intervals. When the level of fear-potentiated startle during the short-term test was lowered to that of the 48-hr test (i.e., by training rats with a lower, 0.3 mA footshock), AP5 abolished fear-potentiated startle at each timepoint. Thus, amygdala NMDA receptors appear to participate in the initial acquisition of fear memories.