BODIPY-Based Multifunctional Nanoparticles for Dual Mode Imaging-Guided Tumor Photothermal and Photodynamic Therapy.
BODIPY-Based Multifunctional Nanoparticles for Dual Mode Imaging-Guided Tumor Photothermal and Photodynamic Therapy.
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DOI：
10.1021/acsabm.3c00083
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发表时间：
2023-03
影响因子：
4.7
通讯作者：
Zhongyan Chen;Yuncong Chen;Yunjian Xu;Xiangchao Shi;Zhong Han;Yang Bai;Hongbao Fang;Weijiang He;Zijian Guo
中科院分区：
文献类型：
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作者：
Zhongyan Chen;Yuncong Chen;Yunjian Xu;Xiangchao Shi;Zhong Han;Yang Bai;Hongbao Fang;Weijiang He;Zijian Guo
集准确、多诊断和高效治疗于一体的多功能纳米颗粒在肿瘤治疗中具有广阔的应用前景。然而，如何开发多功能纳米颗粒用于成像引导下的肿瘤有效清除仍然是一项具有挑战性的任务。本研究通过偶联2,6-二碘-二吡咯甲烷（2,6-二碘- bodipy）和Aza-硼-二吡咯甲烷（Aza- bodipy），制备了一种近红外有机试剂Aza/I-BDP。通过两亲性生物相容性共聚物DSPE-mPEG5000包封，制备出分布均匀的Aza/I-BDP纳米粒子（NPs），具有高氧生成、高光热转化效率和光稳定性。值得注意的是，Aza/I-BDP和DSPE-mPEG5000的共组装有效地抑制了Aza/I-BDP在水溶液中的h聚集，同时亮度提高了31倍。更重要的是，体内实验表明，Aza/I-BDP NPs可能用于近红外荧光和光声成像引导的光动力和光热治疗。
Multifunctional nanoparticles integrating accurate multi-diagnosis and efficient therapy hold great prospects in tumor theranostics. However, it is still a challenging task to develop multifunctional nanoparticles for imaging-guided effective eradication of tumors. Herein, we developed a near-infrared (NIR) organic agent Aza/I-BDP by coupling 2,6-diiodo-dipyrromethene (2,6-diiodo-BODIPY) with aza-boron-dipyrromethene (Aza-BODIPY). Through encapsulating with an amphiphilic biocompatible copolymer DSPE-mPEG5000, well-distributed Aza/I-BDP nanoparticles (NPs) were developed, which exhibited high 1O2 generation, high photothermal conversion efficiency, and excellent photo-stability. Notably, coassembly of Aza/I-BDP and DSPE-mPEG5000 effectively inhibits H-aggregation of Aza/I-BDP in aqueous solution and enhances the brightness simultaneously up to 31-fold. More importantly, in vivo experiments demonstrated that Aza/I-BDP NPs might be used for NIR fluorescent and photoacoustic imaging-guided photodynamic and photothermal therapy.