Where west meets east: The complex mtDNA landscape of the southwest and Central Asian corridor
Where west meets east: The complex mtDNA landscape of the southwest and Central Asian corridor
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DOI：
10.1086/383236
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发表时间：
2004-05-01
影响因子：
9.8
通讯作者：
McElreavey, K
中科院分区：
文献类型：
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作者：
Quintana-Murci, L;Chaix, R;McElreavey, K
西南和中亚走廊在人类历史上发挥了关键作用，见证了不同民族在不同时期的无数次移徙浪潮。为了评估这些人口流动对伊朗高原，印度河流域和中亚地区目前遗传景观的影响，我们分析了该地区23个人口的910个线粒体DNA（mtDNA）。这项研究使一些谱系的系统发育关系的细化和新的单倍型群在西南和中亚mtDNA树的鉴定。这两个谱系的地理分布和分子变异的空间分析表明，人口位于印度河流域西部主要港口的mtDNA的欧亚大陆西部的起源，而那些居住在印度-恒河地区和中亚目前的血统，可以分配到三个不同的遗传组成部分的欧亚大陆西部，欧亚大陆东部和南亚起源的相当大的比例。除了不同起源的谱系集群的整体合成图，我们观察到一些深根谱系，其相对聚类和合并年龄表明在更新世期间在亚洲西南走廊的原地起源。与Y染色体数据的比较揭示了该地区高度复杂的遗传和人口历史，其中包括性不对称的交配模式，创始人效应和东非奴隶贸易的女性特有痕迹。
The southwestern and Central Asian corridor has played a pivotal role in the history of humankind, witnessing numerous waves of migration of different peoples at different times. To evaluate the effects of these population movements on the current genetic landscape of the Iranian plateau, the Indus Valley, and Central Asia, we have analyzed 910 mitochondrial DNAs (mtDNAs) from 23 populations of the region. This study has allowed a refinement of the phylogenetic relationships of some lineages and the identification of new haplogroups in the southwestern and Central Asian mtDNA tree. Both lineage geographical distribution and spatial analysis of molecular variance showed that populations located west of the Indus Valley mainly harbor mtDNAs of western Eurasian origin, whereas those inhabiting the Indo-Gangetic region and Central Asia present substantial proportions of lineages that can be allocated to three different genetic components of western Eurasian, eastern Eurasian, and south Asian origin. In addition to the overall composite picture of lineage clusters of different origin, we observed a number of deep-rooting lineages, whose relative clustering and coalescent ages suggest an autochthonous origin in the southwestern Asian corridor during the Pleistocene. The comparison with Y-chromosome data revealed a highly complex genetic and demographic history of the region, which includes sexually asymmetrical mating patterns, founder effects, and female-specific traces of the East African slave trade.