Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens
Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens
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DOI：
10.1039/c1cc12079d
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Zhang, Wei-Dong
中科院分区：
文献类型：
--
作者：
Lin, Sheng;Shi, Ting;Zhang, Wei-Dong
环青霉酮(1)，具有独特的2，5-二甲基环戊酮-2-烯酮碳骨架，是从真菌德肯青霉的发酵液中分离得到的。结合核磁共振波谱、CD数据和计算方法，确定了1的结构和绝对构型。环青霉酮(1)对脂多糖诱导的RAW264.7巨噬细胞产生NO有剂量依赖性(10-100mU)抑制作用。
Cyclopenicillone (1), possessing a unique 2,5-dimethylcyclopent-2-enone carbon skeleton, has been isolated from the cultures broth of the fungus Penicillium decumbens. The structure and absolute configuration of 1 were elucidated using a combination of NMR spectroscopy, CD data and computational approaches. Cyclopenicillone (1) demonstrated a dose-dependent (10-100 mu M) inhibition against LPS-induced NO production in RAW264.7 macrophages.