Analysis of coherent activity between retrosplenial cortex, hippocampus, thalamus, and anterior cingulate cortex during retrieval of recent and remote context fear memory.
Analysis of coherent activity between retrosplenial cortex, hippocampus, thalamus, and anterior cingulate cortex during retrieval of recent and remote context fear memory.
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DOI：
10.1016/j.nlm.2015.11.019
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发表时间：
2016-01
影响因子：
2.7
通讯作者：
Kay LM
中科院分区：
文献类型：
--
作者：
Corcoran KA;Frick BJ;Radulovic J;Kay LM
背景恐惧条件反射的记忆依赖于压后皮层（RSC），无论条件反射发生多久，而与RSC相连的区域，如背侧海马（DH）和前扣带皮层（ACC）似乎起着时间限制的作用。为了更好地了解这些大脑区域在记忆处理过程中是否在功能上相互作用，以及时间的推移如何影响这些相互作用，我们同时记录了这三个区域以及前背丘脑（ADT）的局部场电位（LFP），ADT为RSC提供了最强的输入之一，并测量了θ（4- 12 Hz）和γ（30- 80 Hz）频带内振荡活动的相干性。我们确定了与编码，检索和灭绝的背景恐惧，而伽马相干性的变化仅限于恐惧灭绝的θ相干性的变化。具体来说，暴露于一个新的背景和检索最近获得的恐惧条件记忆与增加的θ相干RSC和所有其他三个结构。相比之下，RSC-DH和RSC-ADT θ相干性在成功检索的小鼠中降低，相对于未能检索的小鼠，远程记忆。更大的RSC-ADT θ和γ相干性，观察到在最近，相比，远程，灭绝的冻结反应。因此，RSC和连接的大脑区域之间的一致性程度可以预测和有助于上下文记忆检索和检索相关的现象，如恐惧消退。重要的是，虽然在最近的记忆编码和检索过程中，该回路中的θ相干性增加，但未能降低RSC-DH θ相干性可能与长期检索缺陷有关，并可能导致神经精神疾病的异常记忆处理特征。
Memory for contextual fear conditioning relies upon the retrosplenial cortex (RSC) regardless of how long ago conditioning occurred, whereas areas connected to the RSC, such as the dorsal hippocampus (DH) and anterior cingulate cortex (ACC) appear to play time-limited roles. To better understand whether these brain regions functionally interact during memory processing and how the passage of time affects these interactions, we simultaneously recorded local field potentials (LFPs) from these three regions as well as anterior dorsal thalamus (ADT), which provides one of the strongest inputs to RSC, and measured coherence of oscillatory activity within the theta (4–12Hz) and gamma (30–80Hz) frequency bands. We identified changes of theta coherence related to encoding, retrieval, and extinction of context fear, whereas changes in gamma coherence were restricted to fear extinction. Specifically, exposure to a novel context and retrieval of recently acquired fear conditioning memory were associated with increased theta coherence between RSC and all three other structures. In contrast, RSC-DH and RSC-ADT theta coherence were decreased in mice that successfully retrieved, relative to mice that failed to retrieve, remote memory. Greater RSC-ADT theta and gamma coherence were observed during recent, compared to remote, extinction of freezing responses. Thus, the degree of coherence between RSC and connected brain areas may predict and contribute to context memory retrieval and retrieval-related phenomena such as fear extinction. Importantly, although theta coherence in this circuit increases during memory encoding and retrieval of recent memory, failure to decrease RSC-DH theta coherence might be linked to retrieval deficit in the long term, and possibly contribute to aberrant memory processing characteristic of neuropsychiatric disorders.