Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet:: A longitudinal study
Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet:: A longitudinal study
复制标题
DOI：
10.1080/00365520119754
复制
发表时间：
2001-05-01
影响因子：
1.9
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
--
作者：
Addolorato, G;Capristo, E;Gasbarrini, G
背景：据报道，未经治疗的乳糜泻（CD）患者中焦虑和抑郁的患病率较高。目前，无麸质饮食（GFD）对心理障碍的作用仍然知之甚少。本研究的目的是评估成人CD患者在GFD 1年之前和之后的状态和特质焦虑和抑郁。方法：对35例CD患者在GFD治疗前和治疗后1年进行研究。共59名性别、年龄和社会经济状况相匹配的健康受试者作为对照组进行研究。状态和特质焦虑用STAI测试评估：抑郁用SDS Zung抑郁自评量表（M-SDS）的修改版本评估。在GFD前（TO）和GFD 1年后（T1）进行测试。结果如下：在T0，CD患者表现出高水平的状态焦虑，与对照组相比，（71.4%vs23.7%，P < 0.0001），而特质焦虑两组间差异无统计学意义（25.7%对15.2%; P：ns）; CD组抑郁发生率（57.1%）显著高于对照组（9.6%）（P < 0.0001）。在T1。CD患者的状态焦虑百分比显著降低（T0：71.4%vsT1：25.7%，P < 0.001），而特质焦虑百分比（T0：25.7%vsT1：17.1%，P < 0.001）和抑郁百分比（T0：57.1%，P <0.001）无显著变化与T1相比：45.7%：P：ns）。与对照组相比，其在治疗的CD中仍然以显著更高的百分比存在（P < 0.0001）。结论：在CD患者中，焦虑主要以反应性形式存在，GFD后焦虑减少。抑郁症在CD患者中的比例较高，1年的GFD未能显著影响抑郁症状。GFD后抑郁的存在可能与CD患者生活质量的降低有关。GFD后抑郁的不消退提示这些患者需要心理支持。
Background: A high prevalence of anxiety and depression has been reported in untreated coeliac disease (CD) patients. At present, the role of a gluten-free diet (GFD) on psychological disorders is still poorly known. The aim of this study was to evaluate state and trait anxiety and depression in adult CD patients before and after 1 year of GFD. Methods: A total of 35 CD patients were studied before and after 1 year of GFD. A total of 59 healthy subjects matched for gender, age and socio-economic status were studied as a control group. State and trait anxiety were assessed with the STAI test: depression was assessed using the modified version of the SDS Zung self-rating depression scale (M-SDS). The tests were administered before (TO) and after 1 year of GFD (T1). Results: At T0, CD patients showed high levels of state anxiety in a significantly higher percentage compared to controls (71.4% versus 23.7%; P < 0.0001), while there was no significant difference in trait anxiety between groups (25.7% versus 15.2%; P:ns); the percentage of subjects with depression was significantly higher in the CD group than in the control group (57.1% versus 9.6%: P < 0.0001). At T1. a significant decrease in the percentage of state anxiety was found in CD patients (T0: 71.4% versus T1: 25.7%; P < 0.001), while there were no significant changes in the percentage of trait anxiety (T0: 25.7% versus T1: 17.1%; P:ns) or depression (T0: 57.1.% versus T1: 45.7%: P:ns). which was still present in a significantly higher percentage in treated CD compared to controls (P < 0.0001). Conclusion: In CD patients anxiety is present in a predominantly reactive form and it decreases after GFD. Depression is present in a higher percentage in CD patients and 1 year of GFD fails significantly to affect depressive symptoms. The presence of depression after GFD could be related to the reduction in quality of life in CD patients. The non-regression of depression after GFD could suggest that these patients need psychological support.