Prolonged exercise decreases serum leptin concentrations.
Prolonged exercise decreases serum leptin concentrations.
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长时间运动会降低血清瘦素浓度。
DOI：
10.1016/s0026-0495(97)90200-6
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hickner,RC
中科院分区：
文献类型：
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作者：
Landt,M;Lawson,GM;Helgeson,JM;Davila-Roman,VG;Ladenson,JH;Jaffe,AS;Hickner,RC
在两组进行剧烈运动的受试者中测定血清瘦素和游离脂肪酸浓度：12名男性禁食过夜，然后骑固定式测力计2小时，14名非禁食的超级马拉松运动员。在运动前、运动停止后即刻和运动期结束后6至24小时采集血样。整夜禁食后两小时的剧烈踩踏显著降低了平均瘦素水平8.3%;游离脂肪酸高度增加，与血清瘦素的降低相关（r =.737，P = .01）。经过6小时的休息和再喂养，瘦素浓度恢复到运动前的水平和游离脂肪酸浓度下降到低于运动前的水平。同样的血清瘦素水平下降（12.3%）发生在受试者禁食过夜，然后为一段时间对应的周期运动期。与赛前水平相比，长时间的超马拉松运动显著降低了瘦素浓度32%;游离脂肪酸浓度高度增加，但与血清瘦素浓度的变化无关（r = .366，P = .20）。在停止比赛后18至24小时收集的血液样本中，瘦素和游离脂肪酸浓度都趋向于赛前水平。结果表明，负能量平衡的运动可以降低血清瘦素浓度，但显着减少只发生在极端的严重程度/持续时间的运动引起的负平衡。可能的生理作用，减少瘦素浓度的能量平衡和游离脂肪酸介导的反应中的作用进行了讨论。
Serum leptin and free fatty acid concentrations were determined in two groups of subjects undergoing strenuous exercise: 12 men who fasted overnight and then pedaled a stationary ergometer for 2 hours, and 14 nonfasting ultramarathon runners. Blood samples were collected before exercise, immediately after cessation of exercise, and 6 to 24 hours after the end of the exercise period. Two hours of strenuous pedaling following an overnight fast significantly reduced mean leptin levels by 8.3%; free fatty acids were highly increased and correlated well with the decrease in serum leptin (r =.737, P = .01). After 6 hours of rest and refeeding, leptin concentrations recovered to preexercise levels and free fatty acid concentrations were decreased to less than preexercise levels. A similar decrease in serum leptin levels (12.3%) occurred in subjects who fasted overnight and then for a period corresponding to the cycle exercise period. The prolonged exercise of an ultramarathon significantly reduced leptin concentrations by 32% in comparison to prerace levels; free fatty acid concentrations were highly increased, but did not correlate with the change in serum leptin concentrations (r = .366, P = .20). Leptin and free fatty acid concentrations all trended toward prerace levels in blood samples collected 18 to 24 hours after cessation of racing. The results suggest that the negative energy balance of exercise can reduce serum leptin concentrations, but that the significant decrease occurs only at extremes of severity/duration of the exercise-induced negative balance. The possible physiological role of reduced leptin concentrations in response to energy balance and the role of free fatty acids in mediating the response are discussed.